Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel.
Math Biosci. 2012 Dec;240(2):92-113. doi: 10.1016/j.mbs.2012.05.004. Epub 2012 May 30.
We describe a large class of chemical reaction networks, those endowed with a subtle structural property called concordance. We show that the class of concordant networks coincides precisely with the class of networks which, when taken with any weakly monotonic kinetics, invariably give rise to kinetic systems that are injective - a quality that, among other things, precludes the possibility of switch-like transitions between distinct positive steady states. We also provide persistence characteristics of concordant networks, instability implications of discordance, and consequences of stronger variants of concordance. Some of our results are in the spirit of recent ones by Banaji and Craciun, but here we do not require that every species suffer a degradation reaction. This is especially important in studying biochemical networks, for which it is rare to have all species degrade.
我们描述了一大类化学反应网络,这些网络具有一种称为一致性的微妙结构性质。我们表明,一致性网络的类恰好与这样的网络类完全重合,当与任何弱单调动力学一起使用时,这些网络类总是导致动力学系统具有单射性——这种性质除其他外,排除了在不同的正稳定态之间发生类似开关的跃迁的可能性。我们还提供了一致性网络的持久性特征、不一致性的不稳定性含义以及一致性更强变体的后果。我们的一些结果与 Banaji 和 Craciun 的最近结果精神一致,但在这里我们不需要每个物种都经历降解反应。这在研究生化网络时尤为重要,因为很少有所有物种都降解。