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肠聚集性大肠埃希菌噬菌体 VchBan8 的基因组分析：一种霍乱弧菌中的非典型遗传元件。

Genomic analysis of ICEVchBan8: An atypical genetic element in Vibrio cholerae.

机构信息

Maryland Pathogen Research Institute, University of Maryland, College Park, MD 20742, USA.

出版信息

FEBS Lett. 2012 Jun 4;586(11):1617-21. doi: 10.1016/j.febslet.2012.03.064. Epub 2012 Apr 18.

DOI:10.1016/j.febslet.2012.03.064
PMID:22673571
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3612942/
Abstract

Genomic islands (GIs) and integrative conjugative elements (ICEs) are major players in bacterial evolution since they encode genes involved in adaptive functions of medical or environmental importance. Here we performed the genomic analysis of ICEVchBan8, an unusual ICE found in the genome of a clinical non-toxigenic Vibrio cholerae O37 isolate. ICEVchBan8 shares most of its genetic structure with SXT/R391 ICEs. However, this ICE codes for a different integration/excision module is located at a different insertion site, and part of its genetic cargo shows homology to other pathogenicity islands of V. cholerae.

摘要

基因组岛 (GIs) 和整合性接合元件 (ICEs) 是细菌进化的主要参与者，因为它们编码与医学或环境重要性相关的适应性功能基因。在这里，我们对在一株临床非产毒霍乱弧菌 O37 分离株基因组中发现的一种不寻常的 ICEVchBan8 进行了基因组分析。ICEVchBan8 与 SXT/R391 ICEs 共享其大部分遗传结构。然而，这个 ICE 编码的是不同的整合/切除模块，位于不同的插入位点，其部分遗传物质与霍乱弧菌的其他致病性岛具有同源性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78c3/3612942/48d9d4541700/nihms371629f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78c3/3612942/40d6e235163f/nihms371629f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78c3/3612942/12a74efe852b/nihms371629f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78c3/3612942/48d9d4541700/nihms371629f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78c3/3612942/40d6e235163f/nihms371629f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78c3/3612942/12a74efe852b/nihms371629f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78c3/3612942/48d9d4541700/nihms371629f3.jpg

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