Functional Neuroimaging Unit, Centre de recherche de l'institut gériatrique de l'université de Montréal, Québec, Canada; Center of Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Montréal, Québec, Canada; Centre de recherche en neuropsychologie et en cognition, Department of Psychology, University of Montreal, Montreal, Québec, Canada.
Hum Brain Mapp. 2013 Nov;34(11):2918-28. doi: 10.1002/hbm.22116. Epub 2012 Jun 5.
The purpose of this study was to investigate the predictive function of sleep spindles in motor sequence consolidation. BOLD responses were acquired in 10 young healthy subjects who were trained on an explicitly known 5-item sequence using their left nondominant hand, scanned at 9:00 pm while performing that same task and then were retested and scanned 12 h later after a night of sleep during which polysomnographic measures were recorded. An automatic algorithm was used to detect sleep spindles and to quantify their characteristics (i.e., density, amplitude, and duration). Analyses revealed significant positive correlations between gains in performance and the amplitude of spindles. Moreover, significant increases in BOLD signal were observed in several motor-related areas, most of which were localized in the right hemisphere, particularly in the right cortico-striatal system. Such increases in BOLD signal also correlated positively with the amplitude of spindles at several derivations. Taken together, our results show that sleep spindles predict neural and behavioral changes in overnight motor sequence consolidation.
这项研究的目的是探究睡眠纺锤波在运动序列巩固中的预测功能。10 名年轻健康的被试者使用非优势手进行一项明确的 5 项序列任务训练，晚上 9 点进行 BOLD 扫描，然后在一夜睡眠后（期间记录多导睡眠图）进行同样任务的测试和 12 小时后扫描。自动算法用于检测睡眠纺锤波并量化其特征（即密度、幅度和持续时间）。分析显示，表现的提高与纺锤波的幅度呈正相关。此外，在几个与运动相关的区域观察到 BOLD 信号的显著增加，这些区域大部分位于右半球，特别是在右侧皮质-纹状体系统中。BOLD 信号的这种增加也与几个导线上的纺锤波幅度呈正相关。总的来说，我们的结果表明，睡眠纺锤波可以预测夜间运动序列巩固过程中的神经和行为变化。
