Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231-1000, USA.
Semin Radiat Oncol. 2012 Jul;22(3):187-93. doi: 10.1016/j.semradonc.2012.03.002.
Recent data show that human papillomavirus-positive oropharyngeal cancer (OPC) has a distinct biological and clinical behavior compared with human papillomavirus-negative OPC. As this subset of head and neck cancer represents an increasing public health concern, a thorough understanding of the causative and mechanistic differences between these diseases and how these distinctions impact clinical treatment is required. In this review, we will summarize recent data in epidemiology, the mechanism of viral carcinogenesis and differences in tumor biology that may provide insights to improve the clinical management of patients with human papillomavirus-positive OPC.
最近的数据表明，与 HPV 阴性口咽癌 (OPC) 相比，HPV 阳性 OPC 具有明显不同的生物学和临床行为。由于这部分头颈部癌症越来越引起公众健康的关注，因此需要彻底了解这些疾病之间的病因和发病机制差异，以及这些差异如何影响临床治疗。在这篇综述中，我们将总结流行病学、病毒致癌机制和肿瘤生物学差异方面的最新数据，这些数据可能为改善 HPV 阳性 OPC 患者的临床管理提供见解。
