Yang Jianjun, Zhang Tao, Yang Hao, Jiang Huabei
Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611, USA.
Appl Opt. 2012 Jun 1;51(16):3461-9. doi: 10.1364/AO.51.003461.
We describe a multispectral continuous-wave diffuse optical tomography (DOT) system that can be used for in vivo three-dimensional (3-D) imaging of seizure dynamics. Fast 3-D data acquisition is realized through a time multiplexing approach based on a parallel lighting configuration--our system can achieve 0.12 ms per source per wavelength and up to a 14 Hz sampling rate for a full set of data for 3-D DOT image reconstruction. The system is validated using both static and dynamic tissue-like phantoms. An initial in vivo experiment using a rat model of seizure is also demonstrated.
我们描述了一种多光谱连续波扩散光学层析成像（DOT）系统，该系统可用于癫痫发作动态的体内三维（3-D）成像。通过基于并行照明配置的时间复用方法实现快速3-D数据采集——我们的系统每个光源每个波长可实现0.12毫秒，对于用于3-D DOT图像重建的全套数据，采样率高达14赫兹。该系统使用静态和动态组织样体模进行了验证。还展示了使用癫痫大鼠模型进行的初步体内实验。
