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痘苗病毒对修复缺陷型人类细胞的感染会减少γ诱导的DNA断裂的形成

[Infection of repair-deficient human cells by the vaccinia virus decreases the formation of gamma-induced DNA breaks].

作者信息

Sinel'shchikova T A, Gubitskaia E G, Akhmatullina N B, Zasukhina G D

出版信息

Radiobiologiia. 1990 Nov-Dec;30(6):834-6.

PMID:2270288
Abstract

The alkaline elution method was used to study DNA breaks induced by the different mutagens in human cells. Normal fibroblasts and fibroblasts from patients with homocystinuria, deficient in gamma-type repair were shown to be resistant to gamma-radiation after the vaccinia virus infection. In both cell lines there was a decrease in the number of the mutagen-induced DNA breaks.

摘要

采用碱性洗脱法研究不同诱变剂在人细胞中诱导的DNA断裂情况。结果显示，正常成纤维细胞以及来自同型胱氨酸尿症患者且缺乏γ型修复的成纤维细胞，在接种牛痘病毒后对γ辐射具有抗性。在这两种细胞系中，诱变剂诱导的DNA断裂数量均有所减少。

相似文献

1
[Infection of repair-deficient human cells by the vaccinia virus decreases the formation of gamma-induced DNA breaks].痘苗病毒对修复缺陷型人类细胞的感染会减少γ诱导的DNA断裂的形成
Radiobiologiia. 1990 Nov-Dec;30(6):834-6.
2
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Genetika. 1996 Jun;32(6):860-2.
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[Genetic characteristics of repair-deficient cells from patients with homocystinuria].[同型胱氨酸尿症患者修复缺陷细胞的遗传特征]
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DNA repair capacity correlates with mutagen sensitivity in lymphoblastoid cell lines.在淋巴母细胞系中，DNA修复能力与诱变敏感性相关。
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Rejoining kinetics of DNA single- and double-strand breaks in normal and DNA ligase-deficient cells after exposure to ultraviolet C and gamma radiation: an evaluation of ligating activities involved in different DNA repair processes.正常细胞和DNA连接酶缺陷细胞在暴露于紫外线C和γ辐射后DNA单链和双链断裂的重新连接动力学：对不同DNA修复过程中涉及的连接活性的评估
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