沉默调节蛋白1与口腔癌
Sirtuin 1 and oral cancer.
作者信息
Islam Shajedul, Abiko Yoshihiro, Uehara Osamu, Chiba Itsuo
机构信息
Division of Disease Control and Molecular Epidemiology, Department of Oral Growth and Development, School of Dentistry, Health Sciences University of Hokkaido, Tobetsu, Hokkaido 061-0293, Japan.
Division of Oral Medicine and Pathology, Department of Human Biology and Pathophysiology, School of Dentistry, Health Sciences University of Hokkaido, Tobetsu, Hokkaido 061-0293, Japan.
出版信息
Oncol Lett. 2019 Jan;17(1):729-738. doi: 10.3892/ol.2018.9722. Epub 2018 Nov 16.
Abstract
The sirtuins (SIRTs) are a family of highly conserved histone deacetylases (HDACs) consisting of seven members (SIRT1-SIRT7). Over the past few decades, SIRT1 has been the most extensively studied and garnered tremendous attention in the scientific community due to its emerging role in cancer biology. However, its biological role in the regulation of oral cancer is not yet fully understood. Owing to contradictory findings regarding the role of SIRT1 in oral cancer, debate about it continues. The present study discusses the biological roles and potential therapeutic implications of SIRT1 in precancerous oral lesions and oral cancer.
摘要
沉默调节蛋白（SIRTs）是一类高度保守的组蛋白去乙酰化酶（HDACs），由七个成员（SIRT1 - SIRT7）组成。在过去几十年中，SIRT1是研究最为广泛的，并且由于其在癌症生物学中日益凸显的作用而在科学界备受关注。然而，其在口腔癌调控中的生物学作用尚未完全明确。由于关于SIRT1在口腔癌中作用的研究结果相互矛盾，对此的争论仍在继续。本研究探讨了SIRT1在口腔癌前病变和口腔癌中的生物学作用及潜在的治疗意义。
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