Muséum National d'Histoire Naturelle, Molécules de Communication et Adaptation des Micro-organismes (UMR 7245 CNRS-MNHN), 57 rue Cuvier (CP 54), 75005 Paris, France.
Nat Prod Rep. 2012 Aug;29(8):845-69. doi: 10.1039/c2np20037f. Epub 2012 Jun 20.
The Cephalotaxus genus belongs to the Cephalotaxaceae family of conifers. Over the past decades it has proved to be a fruitful source of interesting natural products, especially alkaloids (cephalotaxine esters) and terpenoids (abietanes, troponoids), which often display medicinal properties, especially in the anticancer area. Homoharringtonine is active against some orphan leukaemia and is nowadays approaching marketability. A phytochemical update will be provided and the total synthesis of alkaloids and terpenoids will be discussed in detail.
三尖杉属属于柏科植物。在过去的几十年中，它已被证明是一个富有成效的有趣天然产物的来源，特别是生物碱（三尖杉酯碱）和萜类化合物（松香烷、托品烷），它们通常具有药用特性，特别是在抗癌领域。高三尖杉酯碱对某些孤儿白血病有效，目前已接近市场化。将提供植物化学的最新研究进展，并详细讨论生物碱和萜类化合物的全合成。
