Paden Autonomic Dysfunction Service, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, USA.
Int J Gynaecol Obstet. 2012 Sep;118(3):242-6. doi: 10.1016/j.ijgo.2012.04.014. Epub 2012 Jun 20.
To assess differences in gynecologic history and lightheadedness during menstrual cycle phases among patients with POTS and healthy control women.
In a prospective, questionnaire-based study carried out at Paden Autonomic Dysfunction Center, Vanderbilt University, between April 2005 and January 2009, a custom-designed questionnaire was administered to patients with POTS (n=65) and healthy individuals (n=95). The results were analyzed via Fisher exact test and Mann-Whitney U test.
Patients with POTS reported increased lightheadedness through all phases of the menstrual cycle phases as compared with healthy controls. Both groups experienced the greatest lightheadedness during menses, and a decrease in lightheadedness during the follicular phase. Patients with POTS reported a higher incidence of gynecologic diseases as compared with healthy controls.
The severity of lightheadedness was found to vary during the menstrual cycle, which may relate to changes in estrogen levels. Patients with POTS also reported an increase in estrogen-related gynecologic disease.
评估患有 POTS 和健康对照组女性在月经周期各阶段的妇科病史和头晕之间的差异。
在 2005 年 4 月至 2009 年 1 月期间，在范德比尔特大学 Paden 自主功能障碍中心进行的一项前瞻性、基于问卷的研究中，向 65 名 POTS 患者和 95 名健康个体发放了一份定制的问卷。通过 Fisher 确切检验和 Mann-Whitney U 检验分析结果。
与健康对照组相比，患有 POTS 的患者在月经周期的所有阶段都报告有更多的头晕。两组在月经期间头晕最严重，在卵泡期头晕减轻。与健康对照组相比，患有 POTS 的患者报告妇科疾病的发生率更高。
头晕的严重程度在月经周期中有所变化，这可能与雌激素水平的变化有关。患有 POTS 的患者还报告雌激素相关妇科疾病的发生率增加。
