Laboratory of Genes and Development, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.
Open Biol. 2012 May;2(5):120075. doi: 10.1098/rsob.120075.
Innate immunity relies entirely upon germ-line encoded receptors, signalling components and effector molecules for the recognition and elimination of invading pathogens. The fruit fly Drosophila melanogaster with its powerful collection of genetic and genomic tools has been the model of choice to develop ideas about innate immunity and host-pathogen interactions. Here, we review current research in the field, encompassing all layers of defence from the role of the microbiota to systemic immune activation, and attempt to speculate on future directions and open questions.
先天免疫系统完全依赖于胚系编码的受体、信号成分和效应分子，用于识别和清除入侵的病原体。果蝇 Drosophila melanogaster 拥有强大的遗传和基因组工具集，是发展先天免疫和宿主-病原体相互作用思想的首选模型。在这里，我们综述了该领域的当前研究，涵盖了从微生物组作用到全身免疫激活的所有防御层次，并试图对未来的方向和开放性问题进行推测。
