Fernández M C, Jonas J B, Naumann G O
Augenklinik und Poliklinik, Universität Erlangen-Nürnberg, Bundesrepublik Deutschland.
Fortschr Ophthalmol. 1990;87(5):457-60.
Parapapillary chorioretinal atrophy is present in some, but not all glaucomatous eyes. We examined whether eyes with shallow or with deep optic cupping showed more pronounced parapapillary atrophy. To this end, we analyzed 15 degree color stereo optic disc photographs of 141 eyes of 95 normal subjects and 211 eyes of 120 patients suffering from chronic open-angle glaucoma morphometrically. Optic cup depth was semiquantitatively estimated in a relative score ranging from 0 to 5. It increased significantly with increasing glaucoma damage indicated by smaller neuroretinal rim area, higher visual field loss, decreased retinal nerve fiber layer index and more advanced morphological glaucoma stage. Conversely, optic cup depth was inversely correlated with parapapillary atrophy. It decreased significantly with increasing glaucomatous parapapillary atrophy. When two subgroups of eyes with deep and eyes with shallow cups, were formed, matched for neuroretinal rim area, perimetric defects and retinal nerve fiber layer index, the parapapillary atrophy was found to be significantly more pronounced in the subgroup with shallow optic cups than in the subgroup with deep cupping. We conclude that there is a correlation between shallow optic disc cupping and pronounced parapapillary chorioretinal atrophy. This may indicate a common element in their pathogenesis.
部分但并非所有青光眼患者的眼睛存在视乳头旁脉络膜视网膜萎缩。我们研究了视杯浅或视杯深的眼睛是否表现出更明显的视乳头旁萎缩。为此，我们对95名正常受试者的141只眼睛和120名慢性开角型青光眼患者的211只眼睛的15度彩色立体视盘照片进行了形态学分析。视杯深度通过0至5的相对评分进行半定量估计。随着青光眼损害加重，即神经视网膜边缘面积减小、视野缺损增加、视网膜神经纤维层指数降低以及青光眼形态学分期更严重，视杯深度显著增加。相反，视杯深度与视乳头旁萎缩呈负相关。随着青光眼性视乳头旁萎缩加重，视杯深度显著降低。当根据神经视网膜边缘面积、视野缺损和视网膜神经纤维层指数匹配形成视杯深和视杯浅的两个亚组时，发现视杯浅的亚组比视杯深的亚组视乳头旁萎缩明显更严重。我们得出结论，视盘杯浅与明显的视乳头旁脉络膜视网膜萎缩之间存在相关性。这可能表明它们发病机制中有一个共同因素。
