口腔扁平苔藓患者血清基质金属蛋白酶-3水平
Serum level of matrix metalloproteinase-3 in patients with oral lichen planus.
作者信息
Farzin M, Mardani M, Ghabanchi J, Fattahi M J, Rezaee M, Heydari S T, Andisheh Tadbir A
机构信息
Department of Prosthodontics, Dental School, Shiraz University of Medical Sciences, Shiraz, Iran.
出版信息
Iran Red Crescent Med J. 2012 Jan;14(1):10-3. Epub 2012 Jan 1.
BACKGROUND
Oral Lichen planus (OLP) is a chronic lesion of the oral mucosa with unknown origin. Basement membrane changes are common in OLP and may be mediated by proteases such as matrix metalloproteinase (MMPs) and mast cell chymase. The aim of our study was to evaluate the level of serum MMP-3 in OLP com-pared to normal individuals and assess its clinical significance.
METHODS
Thirty four serum samples from patients diagnosed with OLP (12 males, 22 females, age: 42.2±10.8 years) and 34 serum samples from healthy control subjects (11 males, 23 females, age: 42.5±13.3 years) were collected and MMP-3 concentration was measured by ELISA.
RESULTS
The serum MMP-3 level in OLP patients was higher (21.64±24.31 ng/ml) compared with healthy con-trols (16.52±23.63 ng/ml), but showed no statistically significant difference. A statistically significant difference was demonstrated between the two types of OLP, being more pronounced in the erosive/atrophic form 6).
CONCLUSION
The different clinical appearances of OLP are associated with significant differences in MMP-3 serum level.
背景
口腔扁平苔藓（OLP）是一种病因不明的口腔黏膜慢性病变。基底膜变化在OLP中很常见，可能由基质金属蛋白酶（MMPs）和肥大细胞糜酶等蛋白酶介导。我们研究的目的是评估OLP患者血清MMP - 3水平与正常个体相比的情况，并评估其临床意义。
方法
收集34例经诊断为OLP患者的血清样本（男性12例，女性22例，年龄：42.2±10.8岁）和34例健康对照者的血清样本（男性11例，女性23例，年龄：42.5±13.3岁），采用酶联免疫吸附测定法（ELISA）检测MMP - 3浓度。
结果
OLP患者血清MMP - 3水平（21.64±24.31 ng/ml）高于健康对照者（16.52±23.63 ng/ml），但差异无统计学意义。两种类型的OLP之间存在统计学显著差异，在糜烂/萎缩型中更为明显。
结论
OLP的不同临床表现与MMP - 3血清水平的显著差异相关。
Zotero 插件