乳腺癌的蛋白质组学研究（综述）。
Proteomic studies in breast cancer (Review).
作者信息
Qin Xian-Ju, Ling Bruce X
机构信息
Department of General Surgery, Shanghai Eighth People's Hospital, Shanghai 200235, P.R. China.
出版信息
Oncol Lett. 2012 Apr 1;3(4):735-743. doi: 10.3892/ol.2012.573. Epub 2012 Jan 18.
Abstract
Breast cancer is one of the most common types of invasive cancer in females worldwide. Despite major advances in early cancer detection and emerging therapeutic strategies, further improvement has to be achieved for precise diagnosis to reduce the chance of metastasis and relapses. Recent proteomic technologies have offered a promising opportunity for the identification of new breast cancer biomarkers. Matrix-assisted laser desorption/ionization, time-of-flight mass spectrometry (MALDI-TOF MS) and the derived surface-enhanced laser desorption/ionization mass spectrometry (SELDI-TOF MS) enable the development of high-throughput proteome analysis based on comprehensive reliable biomarkers. In this review, we examined proteomic technologies and their applications, and provided focus on the proteomics-based profiling analyses of tumor tissues/cells in order to identify and confirm novel biomarkers of breast cancer.
摘要
乳腺癌是全球女性中最常见的浸润性癌症类型之一。尽管在早期癌症检测和新兴治疗策略方面取得了重大进展，但仍需进一步改进以实现精确诊断，从而降低转移和复发的几率。最近的蛋白质组学技术为鉴定新的乳腺癌生物标志物提供了一个有前景的机会。基质辅助激光解吸/电离飞行时间质谱（MALDI-TOF MS）及其衍生的表面增强激光解吸/电离质谱（SELDI-TOF MS）能够基于全面可靠的生物标志物开展高通量蛋白质组分析。在本综述中，我们研究了蛋白质组学技术及其应用，并着重介绍了基于蛋白质组学的肿瘤组织/细胞分析，以识别和确认新的乳腺癌生物标志物。
相似文献
1
Proteomic studies in breast cancer (Review).乳腺癌的蛋白质组学研究（综述）。
Oncol Lett. 2012 Apr 1;3(4):735-743. doi: 10.3892/ol.2012.573. Epub 2012 Jan 18.
2
Clinical proteomics in breast cancer: a review.乳腺癌中的临床蛋白质组学：综述
Breast Cancer Res Treat. 2009 Jul;116(1):17-29. doi: 10.1007/s10549-008-0263-3. Epub 2008 Dec 11.
3
Protein profiling for cancer biomarker discovery using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and infrared imaging: a review.利用基质辅助激光解吸/电离飞行时间质谱和红外成像进行癌症生物标志物发现的蛋白质分析：综述。
Anal Chim Acta. 2011 Mar 25;690(1):26-34. doi: 10.1016/j.aca.2011.01.044. Epub 2011 Mar 2.
4
MALDI/SELDI protein profiling of serum for the identification of cancer biomarkers.用于鉴定癌症生物标志物的血清基质辅助激光解吸电离/表面增强激光解吸电离蛋白质谱分析
Methods Mol Biol. 2008;428:125-40. doi: 10.1007/978-1-59745-117-8_7.
5
Advances in MALDI mass spectrometry in clinical diagnostic applications.基质辅助激光解吸电离质谱在临床诊断应用中的进展。
Top Curr Chem. 2014;336:139-75. doi: 10.1007/128_2012_413.
6
Applications of Surface-Enhanced Laser Desorption/Ionization Time-Of-Flight (SELDI-TOF) Mass Spectrometry in Defining Salivary Proteomic Profiles.表面增强激光解吸/电离飞行时间（SELDI-TOF）质谱在确定唾液蛋白质组图谱中的应用。
Open Dent J. 2009 Apr 28;3:74-9. doi: 10.2174/1874210600903010074.
7
Surface-enhanced laser desorption/ionization time-of-flight proteomic profiling of breast carcinomas identifies clinicopathologically relevant groups of patients similar to previously defined clusters from cDNA expression.乳腺癌的表面增强激光解吸/电离飞行时间蛋白质组分析可识别出临床病理相关的患者群体，这些群体与先前通过cDNA表达定义的聚类相似。
Breast Cancer Res. 2008;10(3):R48. doi: 10.1186/bcr2101. Epub 2008 May 29.
8
Proteomic Profiling of Invasive Ductal Carcinoma (IDC) using Magnetic Beads-based Serum Fractionation and MALDI-TOF MS.使用基于磁珠的血清分级分离和基质辅助激光解吸电离飞行时间质谱对浸润性导管癌（IDC）进行蛋白质组分析
J Clin Lab Anal. 2015 Jul;29(4):321-7. doi: 10.1002/jcla.21773. Epub 2014 Aug 17.
9
10
Quality control and quality assessment of data from surface-enhanced laser desorption/ionization (SELDI) time-of flight (TOF) mass spectrometry (MS).表面增强激光解吸/电离（SELDI）飞行时间（TOF）质谱（MS）数据的质量控制与质量评估。
BMC Bioinformatics. 2005 Jul 15;6 Suppl 2(Suppl 2):S5. doi: 10.1186/1471-2105-6-S2-S5.
引用本文的文献
1
Transforming Diagnosis and Therapeutics Using Cancer Genomics.利用癌症基因组学改变诊断和治疗方法。
Cancer Treat Res. 2023;185:15-47. doi: 10.1007/978-3-031-27156-4_2.
2
'Breast Cancer Resistance Likelihood and Personalized Treatment Through Integrated Multiomics'.通过综合多组学技术实现乳腺癌耐药可能性及个性化治疗
Front Mol Biosci. 2022 Apr 14;9:783494. doi: 10.3389/fmolb.2022.783494. eCollection 2022.
3
The Role of ATRA, Natural Ligand of Retinoic Acid Receptors, on EMT-Related Proteins in Breast Cancer: Minireview.维甲酸受体的天然配体 ATRA 在乳腺癌 EMT 相关蛋白中的作用：综述。
Int J Mol Sci. 2021 Dec 12;22(24):13345. doi: 10.3390/ijms222413345.
4
Proteomics and its applications in breast cancer.蛋白质组学及其在乳腺癌中的应用。
Am J Cancer Res. 2021 Sep 15;11(9):4006-4049. eCollection 2021.
5
Peptide barcodes in dogs affected by mitral valve disease with and without pulmonary hypertension using MALDI-TOF MS and LC-MS/MS.采用 MALDI-TOF MS 和 LC-MS/MS 分析伴或不伴肺动脉高压的二尖瓣疾病犬的肽条码。
PLoS One. 2021 Aug 12;16(8):e0255611. doi: 10.1371/journal.pone.0255611. eCollection 2021.
6
Topological integration of RPPA proteomic data with multi-omics data for survival prediction in breast cancer via pathway activity inference.通过途径活性推断，对 RPPA 蛋白质组学数据与多组学数据进行拓扑整合，以进行乳腺癌的生存预测。
BMC Med Genomics. 2019 Jul 11;12(Suppl 5):94. doi: 10.1186/s12920-019-0511-x.
7
Plasma Peptidome Pattern of Breast Cancer Using Magnetic Beads-Based Plasma Fractionation and MALDI-TOF MS: A Case Control Study in Egypt.基于磁珠的血浆分离和基质辅助激光解吸电离飞行时间质谱法检测乳腺癌的血浆肽组模式：埃及的一项病例对照研究
Asian Pac J Cancer Prev. 2019 Jan 25;20(1):175-184. doi: 10.31557/APJCP.2019.20.1.175.
8
New Insights into the Role of Endoplasmic Reticulum Stress in Breast Cancer Metastasis.内质网应激在乳腺癌转移中作用的新见解
J Breast Cancer. 2018 Dec;21(4):354-362. doi: 10.4048/jbc.2018.21.e51. Epub 2018 Nov 23.
9
Advancement of mass spectrometry-based proteomics technologies to explore triple negative breast cancer.基于质谱的蛋白质组学技术在探索三阴性乳腺癌方面的进展。
Mol Biosyst. 2016 Dec 20;13(1):42-55. doi: 10.1039/c6mb00639f.
10
Application of gel-based proteomic technique in female reproductive investigations.基于凝胶的蛋白质组学技术在女性生殖研究中的应用。
J Hum Reprod Sci. 2015 Jan-Mar;8(1):18-24. doi: 10.4103/0974-1208.153121.
本文引用的文献
1
Searching for early breast cancer biomarkers by serum protein profiling of pre-diagnostic serum; a nested case-control study.通过对诊断前血清的血清蛋白质谱进行分析，寻找早期乳腺癌生物标志物；一项巢式病例对照研究。
BMC Cancer. 2011 Aug 26;11:381. doi: 10.1186/1471-2407-11-381.
2
Microarrays in the 2010s: the contribution of microarray-based gene expression profiling to breast cancer classification, prognostication and prediction.微阵列在 21 世纪 10 年代：基于微阵列的基因表达谱分析对乳腺癌分类、预后和预测的贡献。
Breast Cancer Res. 2011 Jun 27;13(3):212. doi: 10.1186/bcr2890.
3
Laser capture microdissection applications in breast cancer proteomics.激光捕获显微切割在乳腺癌蛋白质组学中的应用
Methods Mol Biol. 2011;755:143-54. doi: 10.1007/978-1-61779-163-5_11.
4
A large, consistent plasma proteomics data set from prospectively collected breast cancer patient and healthy volunteer samples.来自前瞻性收集的乳腺癌患者和健康志愿者样本的大型、一致的血浆蛋白质组学数据集。
J Transl Med. 2011 May 27;9:80. doi: 10.1186/1479-5876-9-80.
5
Clinical proteomics of breast cancer.乳腺癌的临床蛋白质组学。
Curr Genomics. 2010 Nov;11(7):528-36. doi: 10.2174/138920210793175930.
6
Breast cancer proteomics: a review for clinicians.乳腺癌蛋白质组学：临床医生的综述。
J Cancer Res Clin Oncol. 2011 Jun;137(6):915-25. doi: 10.1007/s00432-011-0978-0. Epub 2011 Apr 5.
7
Gene signatures of breast cancer progression and metastasis.乳腺癌进展和转移的基因特征。
Breast Cancer Res. 2011 Jan 24;13(1):201. doi: 10.1186/bcr2791.
8
Challenges to developing proteomic-based breast cancer diagnostics.基于蛋白质组学的乳腺癌诊断方法面临的挑战。
OMICS. 2011 May;15(5):251-9. doi: 10.1089/omi.2010.0120. Epub 2011 Feb 19.
9
Meta-data analysis as a strategy to evaluate individual and common features of proteomic changes in breast cancer.元数据分析策略用于评估乳腺癌中蛋白质组变化的个体和共同特征。
Cancer Genomics Proteomics. 2011 Jan-Feb;8(1):1-14.
10
Proteomics approaches: new technologies and clinical applications in breast carcinomas.蛋白质组学方法：乳腺癌中的新技术与临床应用
Gulf J Oncolog. 2011 Jan(9):36-44.
Zotero 插件