Department of Medicine, University of Chicago, Chicago, Illinois, USA.
Sleep. 2012 Jul 1;35(7):977-84. doi: 10.5665/sleep.1964.
To test the hypothesis that recurrent sleep curtailment will result in decreased physical activity in adults at risk for type 2 diabetes.
Two-condition 2-period randomized crossover study.
University General Clinical Research Center.
Eighteen healthy patients with parental history of type 2 diabetes (9 females and 9 males, age 27 yr [standard deviation 3], body mass index 23.7 [2.3] kg/m²).
Two week-long inpatient sessions with 8.5 or 5.5-hr nighttime sleep opportunity. Participants who exercised regularly (39%) could follow their usual exercise routines during both sessions.
Sleep and total body movement were measured by wrist actigraphy and waist accelerometry. Subjective mood and vigor was assessed using visual analog scales. The main outcome was the comparison of total activity counts between sleep conditions. Ancillary endpoints included changes in sedentary, light, and moderate plus vigorous activity, and their association with changes in mood and vigor. Daily sleep was reduced by 2.3 hr (P < 0.001) and total activity counts were 31% lower (P = 0.020) during the 5.5-hr time-in-bed condition. This was accompanied by a 24% reduction in moderate-plus-vigorous activity time (P = 0.005) and more sedentary behavior (+21 min/day; P = 0.020). The decrease in daily activity during the 5.5-hr time-in-bed condition was seen mostly in participants who exercised regularly (-39 versus -4% in exercisers versus nonexercisers; P = 0.027). Sleep loss-related declines in physical activity correlated strongly with declines in subjective vigor (R = 0.90; P < 0.001).
Experimental sleep restriction results in decreased amount and intensity of physical activity in adults at risk for type 2 diabetes.
验证反复睡眠限制会导致 2 型糖尿病高危成年人体力活动减少的假说。
两条件两周期随机交叉研究。
大学综合临床研究中心。
18 名有 2 型糖尿病家族史的健康患者（9 名女性和 9 名男性，年龄 27 岁[标准差 3]，体重指数 23.7[2.3]kg/m²）。
8.5 或 5.5 小时夜间睡眠时间的两周住院期。经常锻炼的参与者（39%）可以在两个阶段遵循他们的常规锻炼计划。
通过腕部活动记录仪和腰部加速度计测量睡眠和全身运动。使用视觉模拟量表评估主观情绪和活力。主要结果是比较睡眠条件下的总活动计数。辅助终点包括久坐、轻度、中度加剧烈活动的变化，以及它们与情绪和活力变化的关系。在 5.5 小时卧床时间条件下，每日睡眠时间减少 2.3 小时（P < 0.001），总活动计数减少 31%（P = 0.020）。这伴随着中度加剧烈活动时间减少 24%（P = 0.005）和更多的久坐行为（+21 分钟/天；P = 0.020）。在 5.5 小时卧床时间条件下，日常活动的减少主要发生在经常锻炼的参与者中（锻炼者减少 39%，而非锻炼者减少 4%；P = 0.027）。与睡眠损失相关的体力活动下降与主观活力下降密切相关（R = 0.90；P < 0.001）。
实验性睡眠限制导致 2 型糖尿病高危成年人的体力活动量和强度下降。
