Johnson Timothy J, Lang Kevin S
Department of Veterinary and Biomedical Sciences; University of Minnesota; Saint Paul, MN USA.
Mob Genet Elements. 2012 Jan 1;2(1):55-58. doi: 10.4161/mge.19626.
Incompatibility group IncA/C plasmids are large, low copy, theta-replicating plasmids that have been described in the literature for over 40 years. However, they have only recently been intensively studied on the genomic level because of their associations with the emergence of multidrug resistance in enteric pathogens of humans and animals. These plasmids are unique among other enterobacterial plasmids in many aspects, including their modular structure and gene content. While the IncA/C plasmid genome structure has now been well defined, many questions remain pertaining to their basic biological mechanisms of dissemination and regulation. Here, we discuss the history of IncA/C plasmids in light of our recent understanding of their population distribution, genomics, and effects on host bacteria.
不相容群IncA/C质粒是大型、低拷贝、以θ方式复制的质粒，在文献中已有40多年的描述。然而，由于它们与人和动物肠道病原体中多药耐药性的出现有关，直到最近才在基因组水平上进行深入研究。这些质粒在许多方面与其他肠杆菌质粒不同，包括它们的模块化结构和基因内容。虽然IncA/C质粒的基因组结构现在已经明确，但关于它们传播和调控的基本生物学机制仍有许多问题。在此，我们根据最近对IncA/C质粒群体分布、基因组学及其对宿主细菌影响的理解，讨论其历史。
