Istituto di Scienze dell'Alimentazione, Consiglio Nazionale delle Ricerche, Avellino, Italy.
Ann N Y Acad Sci. 2012 Jul;1259:95-103. doi: 10.1111/j.1749-6632.2012.06599.x.
Increased consumption of fruit and vegetables can represent an easy strategy to significantly reduce the incidence of cancer. We recently demonstrated that the flavonoid quercetin, naturally present in the diet and belonging to the class of phytochemicals, is able to sensitize several leukemia cell lines and B cells isolated from patients affected by chronic lymphocytic leukemia (B-CLL), in addition to apoptotic inducers (anti-CD95 and rTRAIL). Further, it potentiates the effect of fludarabine, a first-line chemotherapeutic drug used against CLL. The proapoptotic activity of quercetin in cell lines and B-CLL is related to the expression and activity of Mcl-1-antiapoptotic proteins belonging to the Bcl-2 family. Quercetin downregulates Mcl-1 mRNA and protein levels acting on mRNA stability and protein degradation. Considering the low toxicity of the flavonoids toward normal peripheral blood cells, our experimental results are in favor of a potential use of quercetin in adjuvant chemotherapy in CLL or other types of cancer.
增加水果和蔬菜的摄入量可以代表一种简单的策略，可以显著降低癌症的发病率。我们最近证明，类黄酮槲皮素，天然存在于饮食中，属于植物化学物质，能够使几种白血病细胞系和来自慢性淋巴细胞白血病（B-CLL）患者的 B 细胞敏感，除了凋亡诱导剂（抗 CD95 和 rTRAIL）。此外，它还增强了氟达拉滨的作用，氟达拉滨是一种用于治疗 CLL 的一线化疗药物。槲皮素在细胞系和 B-CLL 中的促凋亡活性与属于 Bcl-2 家族的 Mcl-1 抗凋亡蛋白的表达和活性有关。槲皮素通过作用于 mRNA 稳定性和蛋白质降解来下调 Mcl-1 mRNA 和蛋白质水平。鉴于类黄酮对正常外周血细胞的低毒性，我们的实验结果有利于将槲皮素在 CLL 或其他类型癌症的辅助化疗中的潜在应用。
