放线菌素 A 和 tirandamycin A 代谢产物的抗阿米巴特性。
Antiamoebic properties of the actinomycete metabolites echinomycin A and tirandamycin A.
机构信息
Department of Biology, Roger Williams University, One Old Ferry Road, Bristol, RI 02809, USA.
出版信息
Parasitol Res. 2012 Dec;111(6):2473-7. doi: 10.1007/s00436-012-3019-2. Epub 2012 Jul 5.
Abstract
Entamoeba histolytica infects 50 million people per year, causing 100,000 deaths worldwide. The primary treatment for amoebiasis is metronidazole. However, increased pathogen resistance combined with the drug's toxic side effects encourages a search for alternative therapeutic agents. Secondary metabolites from marine bacteria are a promising resource for antiprotozoan drug discovery. In this study, extracts from a collection of marine-derived actinomycetes were screened for antiamoebic properties, and the activities of antibiotics echinomycin A and tirandamycin A are shown. Both antibiotics inhibited the in vitro growth of a E. histolytica laboratory strain (HM-1:IMSS) and a clinical isolate (Colombia, Col) at 30- to 60-μM concentrations. EIC(50) (estimated inhibitory concentration) values were comparable for both antibiotics (44.3-46.3 μM) against the E. histolytica clinical isolate.
摘要
溶组织内阿米巴每年感染 5000 万人，导致全球 10 万人死亡。阿米巴病的主要治疗方法是甲硝唑。然而，病原体耐药性的增加以及药物的毒副作用促使人们寻找替代的治疗药物。海洋细菌的次生代谢产物是抗原生动物药物发现的有前途的资源。在这项研究中，从海洋放线菌中筛选出具有抗阿米巴特性的提取物，并显示出抗生素埃希霉素 A 和 tirandamycin A 的活性。两种抗生素在 30-60 μM 浓度下均抑制实验室株（HM-1:IMSS）和临床分离株（哥伦比亚，Col）的体外生长。两种抗生素对溶组织内阿米巴临床分离株的 EIC（50）（估计抑制浓度）值相当（44.3-46.3 μM）。
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