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年龄相关性黄斑变性视野丧失的定量评估。

Quantification of visual field loss in age-related macular degeneration.

机构信息

Department of Ophthalmology, New York University, New York, New York, United States of America.

出版信息

PLoS One. 2012;7(6):e39944. doi: 10.1371/journal.pone.0039944. Epub 2012 Jun 29.

DOI:10.1371/journal.pone.0039944
PMID:22768178
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3386934/
Abstract

BACKGROUND

An evaluation of standard automated perimetry (SAP) and short wavelength automated perimetry (SWAP) for the central 10-2 visual field test procedure in patients with age-related macular degeneration (AMD) is presented in order to determine methods of quantifying the central sensitivity loss in patients at various stages of AMD.

METHODS

10-2 SAP and SWAP Humphrey visual fields and stereoscopic fundus photographs were collected in 27 eyes of 27 patients with AMD and 22 eyes of 22 normal subjects.

RESULTS

Mean Deviation and Pattern Standard Deviation (PSD) varied significantly with stage of disease in SAP (both p<0.001) and SWAP (both p<0.001), but post hoc analysis revealed overlap of functional values among stages. In SWAP, indices of focal loss were more sensitive to detecting differences in AMD from normal. SWAP defects were greater in depth and area than those in SAP. Central sensitivity (within 1°) changed by -3.9 and -4.9 dB per stage in SAP and SWAP, respectively. Based on defect maps, an AMD Severity Index was derived.

CONCLUSIONS

Global indices of focal loss were more sensitive to detecting early stage AMD from normal. The SWAP sensitivity decline with advancing stage of AMD was greater than in SAP. A new AMD Severity Index quantifies visual field defects on a continuous scale. Although not all patients are suitable for SWAP examinations, it is of value as a tool in research studies of visual loss in AMD.

摘要

背景

为了确定在 AMD 不同阶段量化患者中心敏感性损失的方法，对年龄相关性黄斑变性（AMD）患者的中央 10-2 视野测试程序中的标准自动视野计（SAP）和短波长自动视野计（SWAP）进行了评估。

方法

在 27 例 AMD 患者的 27 只眼和 22 例正常对照者的 22 只眼中收集了 10-2 SAP 和 SWAP Humphrey 视野和立体眼底照片。

结果

SAP（均 p<0.001）和 SWAP（均 p<0.001）中平均偏差和模式标准偏差（PSD）随疾病阶段显著变化，但事后分析显示各阶段功能值存在重叠。在 SWAP 中，焦点损失指数更能敏感地检测出 AMD 与正常之间的差异。SWAP 缺陷的深度和面积大于 SAP。SAP 和 SWAP 中中心敏感性（在 1°内）分别下降了-3.9 和-4.9 dB/阶段。根据缺陷图，得出了 AMD 严重指数。

结论

焦点损失的全局指数更能敏感地检测出早期 AMD 与正常之间的差异。SWAP 中随着 AMD 阶段的进展，敏感性下降比 SAP 更明显。新的 AMD 严重指数在连续尺度上量化了视野缺陷。虽然并非所有患者都适合 SWAP 检查，但它是 AMD 视觉损失研究中的有用工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ee/3386934/33f6b89be1df/pone.0039944.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ee/3386934/7c20f5de9648/pone.0039944.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ee/3386934/4dc2742de750/pone.0039944.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ee/3386934/6f61e2a6d21f/pone.0039944.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ee/3386934/8342cb091e36/pone.0039944.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ee/3386934/d7345272c7ab/pone.0039944.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ee/3386934/3d5aa0c6e486/pone.0039944.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ee/3386934/33f6b89be1df/pone.0039944.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ee/3386934/7c20f5de9648/pone.0039944.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ee/3386934/4dc2742de750/pone.0039944.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ee/3386934/6f61e2a6d21f/pone.0039944.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ee/3386934/8342cb091e36/pone.0039944.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ee/3386934/d7345272c7ab/pone.0039944.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ee/3386934/3d5aa0c6e486/pone.0039944.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ee/3386934/33f6b89be1df/pone.0039944.g007.jpg

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