Université de Lyon, F-69622, Lyon, France.
Drug Discov Today. 2012 Oct;17(19-20):1147-54. doi: 10.1016/j.drudis.2012.06.014. Epub 2012 Jul 6.
In this short review we highlight novel uses of silica-based nanoparticles (NPs) in the biomedical sector. Silica NPs are widely used in nanotechnology because they are easy to prepare and inexpensive to produce. Their specific surface characteristics, porosity and capacity for functionalization make them good tools for biomolecule detection and separation, providing solid media for drug delivery systems and acting as contrast agent protectors. In addition, they are used as safety and biocompatible pharmaceutical additives. Here, we focus on novel techniques based on silica NPs for the most important biomedical applications.
在这篇简短的综述中，我们重点介绍了基于二氧化硅的纳米粒子（NPs）在生物医学领域的新用途。二氧化硅 NPs 在纳米技术中得到了广泛的应用，因为它们易于制备且生产成本低廉。其特殊的表面特性、多孔性和功能化能力使它们成为生物分子检测和分离的良好工具，为药物输送系统提供了固体介质，并充当了对比剂保护剂。此外，它们还被用作安全且具有生物相容性的药物添加剂。在这里，我们重点介绍基于二氧化硅 NPs 的新技术在最重要的生物医学应用中的应用。
