AMP 激活的蛋白激酶在肝脏内分泌代谢调控中的新作用。
Emerging role of AMP-activated protein kinase in endocrine control of metabolism in the liver.
机构信息
Department of Molecular Physiology and Biophysics and Mouse Metabolic Phenotyping Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
出版信息
Mol Cell Endocrinol. 2013 Feb 25;366(2):152-62. doi: 10.1016/j.mce.2012.06.018. Epub 2012 Jul 14.
Abstract
This review summarizes the emerging role of AMP-activated protein kinase (AMPK) in mediating endocrine regulation of metabolic fluxes in the liver. There are a number of hormones which, when acting on the liver, alter AMPK activation. Here we describe those hormones associated with activation and de-activation of AMPK and the potential mechanisms for changes in AMPK activation state. The actions of these hormones, in many cases, are consistent with downstream effects of AMPK signaling thus strengthening the circumstantial case for AMPK-mediated hormone action. In recent years, genetic mouse models have also been used in an attempt to establish the role of AMPK in hormone-stimulated metabolism in the liver. Few experiments have, however, firmly established a causal relationship between hormone action at the liver and AMPK signaling.
摘要
这篇综述总结了 AMP 激活的蛋白激酶（AMPK）在介导肝脏代谢通量的内分泌调节中的新作用。有许多激素作用于肝脏时会改变 AMPK 的激活。在这里，我们描述了与 AMPK 激活和失活相关的激素，以及 AMPK 激活状态变化的潜在机制。在许多情况下，这些激素的作用与 AMPK 信号下游的效应一致，因此加强了 AMPK 介导的激素作用的情况。近年来，遗传小鼠模型也被用于尝试确定 AMPK 在激素刺激的肝脏代谢中的作用。然而，很少有实验能确定激素在肝脏中的作用与 AMPK 信号之间的因果关系。
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