Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.
Cell Adh Migr. 2012 Jul-Aug;6(4):346-55. doi: 10.4161/cam.21294. Epub 2012 Jul 1.
Tumors contain a vastly complicated cellular network that relies on local communication to execute malignant programs. The molecular cues that are involved in cell-cell adhesion orchestrate large-scale tumor behaviors such as proliferation and invasion. We have recently begun to appreciate that many tumors contain a high degree of cellular heterogeneity and are organized in a cellular hierarchy, with a cancer stem cell (CSC) population identified at the apex in multiple cancer types. CSCs reside in unique microenvironments or niches that are responsible for directing their behavior through cellular interactions between CSCs and stromal cells, generating a malignant social network. Identifying cell-cell adhesion mechanisms in this network has implications for the basic understanding of tumorigenesis and the development of more effective therapies. In this review, we will discuss our current understanding of cell-cell adhesion mechanisms used by CSCs and how these local interactions have global consequences for tumor biology.
肿瘤包含一个极其复杂的细胞网络，该网络依赖于局部通讯来执行恶性程序。参与细胞间黏附的分子线索协调大规模的肿瘤行为，如增殖和侵袭。我们最近开始意识到，许多肿瘤具有高度的细胞异质性，并以细胞层次组织起来，在多种癌症类型中，顶端是癌症干细胞 (CSC) 群体。CSC 存在于独特的微环境或龛位中，通过 CSC 与基质细胞之间的细胞相互作用来指导其行为，从而产生恶性社交网络。识别该网络中的细胞-细胞黏附机制对于理解肿瘤发生的基本原理和开发更有效的治疗方法具有重要意义。在这篇综述中，我们将讨论我们目前对 CSC 所使用的细胞-细胞黏附机制的理解，以及这些局部相互作用如何对肿瘤生物学产生全局影响。
