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HIV 治疗即预防：争议与评论——早期感染是否会影响治疗即预防策略？

HIV treatment as prevention: debate and commentary--will early infection compromise treatment-as-prevention strategies?

机构信息

Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, United States of America.

出版信息

PLoS Med. 2012;9(7):e1001232. doi: 10.1371/journal.pmed.1001232. Epub 2012 Jul 10.

DOI:10.1371/journal.pmed.1001232
PMID:22802728
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3393667/
Abstract

Universal HIV testing and immediate antiretroviral therapy for infected individuals has been proposed as a way of reducing the transmission of HIV and thereby bringing the HIV epidemic under control. It is unclear whether transmission during early HIV infection--before individuals are likely to have been diagnosed with HIV and started on antiretroviral therapy--will compromise the effectiveness of treatment as prevention. This article presents two opposing viewpoints by Powers, Miller, and Cohen, and Williams and Dye, followed by a commentary by Fraser.

摘要

普遍进行 HIV 检测并对感染者立即进行抗逆转录病毒治疗，这一做法被提议用于降低 HIV 的传播，从而控制 HIV 疫情。目前尚不清楚在早期 HIV 感染期（在个体可能被诊断出 HIV 并开始接受抗逆转录病毒治疗之前）是否会传播 HIV，从而影响治疗即预防的效果。本文介绍了 Powers、Miller 和 Cohen 以及 Williams 和 Dye 的两种相反观点，随后 Fraser 对其进行了评论。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf8d/3393667/700c6c5250f4/pmed.1001232.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf8d/3393667/700c6c5250f4/pmed.1001232.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf8d/3393667/700c6c5250f4/pmed.1001232.g001.jpg

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