加拿大一个关于粪便微生物疗法的工作组报告：微生物生态系统疗法。
A Canadian Working Group report on fecal microbial therapy: microbial ecosystems therapeutics.
作者信息
Allen-Vercoe Emma, Reid Gregor, Viner Norman, Gloor Gregory B, Hota Susy, Kim Peter, Lee Christine, O'Doherty Kieran, Vanner Stephen J, Weese J Scott, Petrof Elaine O
机构信息
University of Guelph, Guelph.
出版信息
Can J Gastroenterol. 2012 Jul;26(7):457-62. doi: 10.1155/2012/213828.
Abstract
A working group from across Canada comprised of clinician and basic scientists, epidemiologists, ethicists, Health Canada regulatory authorities and representatives of major funding agencies (Canadian Institutes of Health Research and the Crohn's and Colitis Foundation of Canada) met to review the current experience with fecal microbial therapy and to identify the key areas of study required to move this field forward. The report highlights the promise of fecal microbial therapy and related synthetic stool therapy (together called 'microbial ecosystems therapeutics') for the treatment of Clostridium difficile colitis and, possibly, other disorders. It identifies pressing clinical issues that need to be addressed as well as social, ethical and regulatory barriers to the use of these important therapies.
摘要
一个由加拿大各地的临床医生、基础科学家、流行病学家、伦理学家、加拿大卫生部监管机构以及主要资助机构（加拿大卫生研究院和加拿大克罗恩病与结肠炎基金会）代表组成的工作组召开会议，审查粪便微生物疗法的当前经验，并确定推动该领域发展所需的关键研究领域。该报告强调了粪便微生物疗法及相关合成粪便疗法（统称为“微生物生态系统疗法”）在治疗艰难梭菌结肠炎以及可能的其他疾病方面的前景。它指出了需要解决的紧迫临床问题以及使用这些重要疗法的社会、伦理和监管障碍。
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