Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Baoding 071002, China.
Molecules. 2012 Jul 17;17(7):8554-60. doi: 10.3390/molecules17078554.
Two new oxysporone derivatives, pestalrone A (1) and pestalrone B (2), along with two known structurally related compounds 3, 4, were from the fermentation broth of the endophytic plant fungus Pestalotiopsis karstenii isolated from stems of Camellia sasanqua. Their structures and relative configurations were elucidated by extensive spectroscopic analysis and comparison of chemical shifts with related known compounds. Compound 2 exhibited significant activities agains HeLa, HepG2 and U-251 with IC₅₀ values of 12.6, 31.7 and 5.4 µg/mL, respectively.
两种新的氧杂孢酮衍生物，pestalrone A（1）和 pestalrone B（2），以及两种已知的结构相关化合物 3、4，是从内生植物真菌 Pestalotiopsis karstenii 的发酵液中分离得到的，该真菌分离自山茶花的茎。通过广泛的光谱分析和与相关已知化合物的化学位移比较，确定了它们的结构和相对构型。化合物 2 对 HeLa、HepG2 和 U-251 表现出显著的活性，IC₅₀ 值分别为 12.6、31.7 和 5.4 µg/mL。
