Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Head Neck. 2013 Aug;35(8):1096-100. doi: 10.1002/hed.23085. Epub 2012 Jul 17.
Head and neck squamous cell carcinoma (HNSCC) is associated with tobacco use. Still, most smokers do not develop HNSCC. The mechanisms of varying susceptibility to HNSCC are poorly studied to date. Tobacco metabolite research provides insight regarding the innate metabolism and excretion of carcinogens.
Smokers with HNSCC (cases) were compared with smokers without HNSCC (controls) in a matched cohort. The tobacco metabolites studied were: 1-hydroxypyrene (1-HOP), N'-nitrosonornicotine (NNN), and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL).
In 33 subjects, mean 1-HOP was 1.82 pmol/mg creatinine versus 1.08 pmol/mg creatinine (p = .004) and mean NNN was 0.10 pmol/mg creatinine versus 0.04 pmol/mg creatinine (p = .01) in cases and controls, respectively. NNAL did not differ between groups.
Smokers with HNSCC have elevated urinary levels of 1-HOP and total NNN compared with matched controls, suggesting an increased effective exposure to these carcinogens. Tobacco constituent metabolites may be useful in understanding tobacco-related carcinogenesis in HNSCC.
头颈部鳞状细胞癌（HNSCC）与烟草使用有关。尽管如此，大多数吸烟者并未发展为 HNSCC。迄今为止，对 HNSCC 易感性差异的机制研究甚少。烟草代谢物研究为了解致癌物的先天代谢和排泄提供了线索。
在匹配队列中，将患有 HNSCC 的吸烟者（病例）与没有 HNSCC 的吸烟者（对照）进行比较。研究的烟草代谢物为：1-羟基芘（1-HOP）、N'-亚硝基降烟碱（NNN）和 4-（甲基亚硝氨基）-1-（3-吡啶基）-1-丁醇（NNAL）。
在 33 名受试者中，病例组的平均 1-HOP 为 1.82 pmol/mg 肌酐，而对照组为 1.08 pmol/mg 肌酐（p =.004），病例组的平均 NNN 为 0.10 pmol/mg 肌酐，而对照组为 0.04 pmol/mg 肌酐（p =.01）。两组间 NNAL 无差异。
与匹配的对照组相比，患有 HNSCC 的吸烟者尿液中 1-HOP 和总 NNN 的水平升高，这表明这些致癌物的有效暴露增加。烟草成分代谢物可能有助于理解 HNSCC 中与烟草相关的致癌作用。
