Szukalska Marta, Szyfter Krzysztof, Florek Ewa, Rodrigo Juan P, Rinaldo Alessandra, Mäkitie Antti A, Strojan Primož, Takes Robert P, Suárez Carlos, Saba Nabil F, Braakhuis Boudewijn J M, Ferlito Alfio
Laboratory of Environmental Research, Department of Toxicology, Poznan University of Medical Sciences, 60-631 Poznan, Poland.
Institute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland.
Cancers (Basel). 2020 Nov 5;12(11):3274. doi: 10.3390/cancers12113274.
E-cigarettes have become increasingly popular in the last decade and are considered less harmful than traditional tobacco products due to the lower content of toxic and carcinogenic compounds. However, this is still a controversial issue. This paper contains a review of previous reports on the composition of e-cigarettes and their impact on the pathogenesis and risk of head and neck cancer (HNC). The objective of the review was to compare the molecular and health effects of e-cigarette use in relation to the effects of traditional cigarette smoking in the upper respiratory tract, and to assess the safety and effect of e-cigarettes on HNC risk. A review for English language articles published until 31 August 2020 was made, using a PubMed (including MEDLINE), CINAHL Plus, Embase, Cochrane Library and Web of Science data. The authors reviewed articles on both toxic and carcinogenic compounds contained in e-cigarettes and their molecular and health effects on the upper respiratory tract in comparison to tobacco cigarettes. The risk of developing head and neck squamous cell carcinoma (HNSCC) remains lower in users of e-cigarettes compared with tobacco smokers. However, more long-term studies are needed to better address the safety of e-cigarettes.
在过去十年中，电子烟越来越受欢迎，由于其有毒和致癌化合物含量较低，被认为比传统烟草产品危害更小。然而，这仍然是一个有争议的问题。本文包含了对先前关于电子烟成分及其对头颈部癌症（HNC）发病机制和风险影响的报告的综述。该综述的目的是比较使用电子烟与传统吸烟在上呼吸道的分子和健康影响，并评估电子烟对HNC风险的安全性和影响。使用PubMed（包括MEDLINE）、CINAHL Plus、Embase、Cochrane图书馆和科学网数据，对截至2020年8月31日发表的英文文章进行了综述。作者回顾了关于电子烟中所含有毒和致癌化合物及其与烟草香烟相比对上呼吸道的分子和健康影响的文章。与吸烟者相比，电子烟使用者患头颈部鳞状细胞癌（HNSCC）的风险仍然较低。然而，需要更多的长期研究来更好地解决电子烟的安全性问题。
