Ma Rui, Söntges Sebastian, Shoham Shy, Ntziachristos Vasilis, Razansky Daniel
Institute for Biological and Medical Imaging, Technical University of Munich and Helmholtz Center Munich, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany.
Biomed Opt Express. 2012 Jul 1;3(7):1724-31. doi: 10.1364/BOE.3.001724. Epub 2012 Jun 26.
The hybrid nature of optoacoustic imaging might impose limitations on concurrent placement of optical and ultrasonic detection components, especially in high resolution microscopic applications that require dense arrangements and miniaturization of components. This hinders optimal deployment of the optical excitation and ultrasonic detection paths, leading to reduction of imaging speed and spatial resolution performance. We suggest a compact coaxial design for optoacoustic microscopy that allows optimizing both the light illumination and ultrasonic detection parameters of the imaging system. System performance is showcased in phantoms and in vivo imaging of microvasculature, achieving real time operation in two dimensions and penetration of 6 mm into optically dense human tissues.
光声成像的混合特性可能会对光学和超声检测组件的同时放置造成限制，尤其是在需要组件密集排列和小型化的高分辨率微观应用中。这阻碍了光激发和超声检测路径的优化部署，导致成像速度和空间分辨率性能下降。我们提出了一种用于光声显微镜的紧凑型同轴设计，该设计能够优化成像系统的光照明和超声检测参数。在仿体和微血管的体内成像中展示了系统性能，实现了二维实时操作，并能穿透6毫米厚的光学致密人体组织。
