Medical Toxicology Research Center, School of Medicine, Mashhad University of Medical Sciences, and Department of Clinical Bacteriology, Ghaem University Hospital, Mashhad, Iran.
Food Chem Toxicol. 2012 Oct;50(10):3826-32. doi: 10.1016/j.fct.2012.07.006. Epub 2012 Jul 15.
Dietary supplements have been used for decades for enhancing muscle growth. The harm caused by some of these products is well documented. We investigated and reported toxic hepatitis in 20 male athletes following self-prescribing of a number of dietary supplements which are lesser known. The patients' ages ranged from 24 to 32 with a mean of 28 years. They had taken three kinds of supplements for 1 year including testosterone optimizer agent T Bomb II, a creatine supplement Phosphagen and an amino acid based supplement Cell-Tech. Based on the history, clinical examination, and laboratory findings the cases were diagnosed as toxic hepatitis. After discontinuation of taking the supplements, clinical recovery and improvement of liver function tests were achieved within 30 days. Causality assessment with the CIOMS (Council for International Organization Medical Sciences) scale showed a "possible" grade of causality (+5 points) for these supplements. It can be concluded that these newer anabolic supplements may induce toxic hepatitis. Since the health risks of them may be severe, the use of these kinds of dietary supplements should be discouraged.
膳食补充剂已被用于增强肌肉生长数十年。这些产品中的一些造成的危害已有充分记录。我们调查并报告了 20 名男性运动员因自行服用一些不太知名的膳食补充剂而导致的中毒性肝炎。患者年龄 24 至 32 岁，平均 28 岁。他们服用了三种补充剂，包括睾丸激素优化剂 T Bomb II、肌酸补充剂 Phosphagen 和基于氨基酸的补充剂 Cell-Tech。根据病史、临床检查和实验室结果，这些病例被诊断为中毒性肝炎。停止服用补充剂后，在 30 天内实现了临床康复和肝功能测试的改善。CIOMS（国际医学科学组织理事会）量表的因果关系评估表明，这些补充剂的因果关系为“可能”（+5 分）。可以得出结论，这些较新的合成代谢补充剂可能会引起中毒性肝炎。由于它们的健康风险可能很严重，应劝阻使用这些类型的膳食补充剂。
