一项关于消化性溃疡出血病因变化的研究。
A study of the changes in the cause of peptic ulcer bleeding.
作者信息
Fujinami Haruka, Kudo Takahiko, Hosokawsa Ayumu, Ogawa Kohei, Miyazaki Takako, Nishikawa Jun, Kajiura Shinya, Ando Takayuki, Ueda Akira, Sugiyama Toshiro
机构信息
Haruka Fujinami, Takahiko Kudo, Ayumu Hosokawsa, Kouhei Ogawa, Takako Miyazaki, Jun Nishikawa, Shinya Kajiura, Takayuki Ando, Akira Ueda, Toshiro Sugiyama, Department of Gastroenterology, University of Toyama, 2630 Sugitani, Toyama 9300194, Japan.
出版信息
World J Gastrointest Endosc. 2012 Jul 16;4(7):323-7. doi: 10.4253/wjge.v4.i7.323.
AIM
To clarify the frequency of and changes in the cause of peptic ulcer bleeding.
METHODS
This study retrospectively evaluated the out- and inpatients who underwent endoscopy between 2002 to 2008. The subjects were patients presenting with peptic ulcer bleeding. The details of these patients were obtained from their endoscopic reports and medical records.
RESULTS
The rates of Helicobacter pylori (H. pylori) infection were significantly low (P = 0.039), while the proportion of nonsteroidal antiinflammatory drugs (NSAIDs) users and vascular disease significantly increased over the period studied (P = 0.034 and P = 0.04, respectively). However, there was no significant difference in the proportion of low-dose aspirin users (P = 0.832).
CONCLUSION
It's found that the primary cause of peptic ulcer bleeding changed from H. pylori infection to use of NSAIDs over the 7-year period of study. It seems that the number of low-dose aspirin users has increased with the increase in the proportion of vascular disease. It is necessary to take measures to prevent peptic ulcer bleeding among NSAIDs and low dose aspirin users.
目的
明确消化性溃疡出血的发生率及病因变化。
方法
本研究回顾性评估了2002年至2008年间接受内镜检查的门诊和住院患者。研究对象为出现消化性溃疡出血的患者。这些患者的详细信息来自其内镜检查报告和病历。
结果
幽门螺杆菌（H. pylori）感染率显著降低（P = 0.039），而在研究期间，非甾体抗炎药（NSAIDs）使用者和血管疾病的比例显著增加（分别为P = 0.034和P = 0.04）。然而，低剂量阿司匹林使用者的比例没有显著差异（P = 0.832）。
结论
研究发现，在7年的研究期间，消化性溃疡出血的主要病因从幽门螺杆菌感染转变为使用NSAIDs。随着血管疾病比例的增加，低剂量阿司匹林使用者的数量似乎也有所增加。有必要采取措施预防NSAIDs和低剂量阿司匹林使用者发生消化性溃疡出血。
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