Department of Pharmacology, University College of Medical Sciences (University of Delhi), Delhi 110095, India.
Inflammation. 2012 Dec;35(6):1900-3. doi: 10.1007/s10753-012-9512-z.
The present study was performed to explore the effect of aqueous extract of Aloe vera on behavioural parameters of pain. Pain assessment was performed by the tail-flick and formalin tests. A. vera (100 mg/kg, per oral (p.o.)) produced an insignificant decrease in the pain response in the tail-flick and formalin tests. Moreover, A. vera (200 and 400 mg/kg, p.o.) did not have significant effect on the tail-flick test. However, A. vera (200 and 400 mg/kg, p.o.) significantly decreased the second phase of the formalin-induced pain. Thus, these findings suggest that A. vera exerts its effect by a peripheral mechanism of action rather than central.
本研究旨在探讨芦荟水提取物对疼痛行为参数的影响。疼痛评估采用尾巴闪烁和福尔马林试验进行。芦荟（100mg/kg，口服（p.o.））对尾巴闪烁和福尔马林试验中的疼痛反应无显著降低作用。此外，芦荟（200 和 400mg/kg，p.o.）对尾巴闪烁试验无显著影响。然而，芦荟（200 和 400mg/kg，p.o.）显著降低了福尔马林诱导疼痛的第二阶段。因此，这些发现表明，芦荟通过外周作用机制发挥作用，而不是中枢作用机制。
