Division of Plastic Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
J Surg Res. 2012 Nov;178(1):330-8. doi: 10.1016/j.jss.2012.06.048. Epub 2012 Jul 15.
Chronic wounds continue to represent a difficult and complex problem for both patients and healthcare providers. Bacterial biofilms represent a critical component of nonhealing wounds, utilizing several different mechanisms to inhibit innate inflammatory pathways and resist traditional therapeutics. Although in vitro biofilm systems have been well described and studied, understanding the intricacies of wound biofilm pathology requires appropriate in vivo models to understand the interactions between bacteria and host. In an effort to clarify the available literature, this review describes and critically evaluates all of the in vivo wound biofilm models currently published to-date, including model advantages and clinical applicability. We will also address the need for continued therapeutic development and testing using these currently available in vivo models.
慢性创面仍然是患者和医疗保健提供者面临的一个困难和复杂的问题。细菌生物膜是难愈创面的一个关键组成部分，它利用多种不同的机制来抑制固有炎症途径并抵抗传统疗法。尽管体外生物膜系统已经得到了很好的描述和研究，但要了解创面生物膜病理学的复杂性，需要使用适当的体内模型来了解细菌和宿主之间的相互作用。为了阐明现有文献，本综述描述并批判性地评估了迄今为止所有已发表的体内创面生物膜模型，包括模型的优点和临床适用性。我们还将讨论使用这些现有的体内模型继续进行治疗开发和测试的必要性。
