Zhenjun D, Lown J W
Chinese International Intellectual Development Center, Beijing, People's Republic of China.
Photochem Photobiol. 1990 Sep;52(3):609-16. doi: 10.1111/j.1751-1097.1990.tb01807.x.
Hypocrellins A and B are pigments which are isolated from parasitic fungi Hypocrella bambuase (B. et Br) sacc. and Shiraia bambusicola P. Heen found in the People's Republic of China (P.R.C.) and Sri Lanka respectively. These agents, which belong to the general class of perylene quinonoid pigments, have a long history of traditional medicinal agents especially in the P.R.C. Recently their marked photosensitizing properties have been established and exploratory studies initiated. This effort has led to the realization of the potential of the hypocrellins for the photodynamic therapy of tumors. The review summarizes the chemical and photophysical properties of the hypocrellins and their derivatives as well as studies on photosensitization to date at the molecular, cellular and in vivo levels, and their prospects as PDT agents.
竹红菌素A和B是分别从中华人民共和国和斯里兰卡发现的寄生真菌竹红菌（Hypocrella bambuase (B. et Br) sacc.）和竹黄菌（Shiraia bambusicola P. Heen）中分离得到的色素。这些物质属于苝醌类色素，尤其是在中华人民共和国，作为传统药物有着悠久的历史。最近，它们显著的光敏特性已得到证实，并已开展探索性研究。这项工作使人们认识到竹红菌素在肿瘤光动力治疗方面的潜力。本文综述了竹红菌素及其衍生物的化学和光物理性质，以及迄今为止在分子、细胞和体内水平上的光敏化研究，及其作为光动力治疗剂的前景。
