Department of Internal Medicine, Pulmonology and Allergology, Medical University of Warsaw, Poland.
Arch Med Sci. 2012 Jul 4;8(3):477-83. doi: 10.5114/aoms.2012.29403.
Low-grade systemic inflammation plays an important role in the pathogenesis and natural history of chronic obstructive pulmonary disease (COPD) and peripheral arterial disease (PAD). The aim of the study was to analyze plasma concentrations of selected markers of inflammation in patients suffering from PAD with or without coexistent COPD.
Thirty patients (6 women) with advanced PAD (at least IIb stage according to Fontaine scale) hospitalized due to critical limb ischemia were examined. In all patients spirometry was performed to confirm or exclude COPD. Plasma concentration of IL-6, IL-8 and TNF-α was measured using ELISA method. Statistical analysis was performed according to COPD status and according to smoking status independently.
In the whole group of patients with PAD, COPD was recognized in 14 cases (for the first time in 10 cases). All patients were smokers (46.7% current, 53.3% ex-smokers). We found a significant correlation between FEV1%N (percent of norm of first second expiratory volume) and the number of years of smoking (r = -0.39; p < 0.05). We found similar concentrations of IL-6 (2.54 pg/ml vs. 2.31 pg/ml), IL-8 (8.55 pg/ml vs. 8.14 pg/ml, TNF-α (0.72 pg/ml vs. 1.75 pg/ml) in the COPD(+) group in comparison to the COPD(-) group (differences were not significant). We observed significant positive correlations (p < 0.05) between concentrations of measured markers and significant negative correlations between pain free walking distance and these markers.
Our study confirmed coexistence of PAD with COPD. The character of inflammation is similar in these smoking-related diseases.
低度全身炎症在慢性阻塞性肺疾病（COPD）和外周动脉疾病（PAD）的发病机制和自然史中起着重要作用。本研究的目的是分析患有 PAD 合并或不合并 COPD 的患者的炎症标志物血浆浓度。
检查了 30 名（6 名女性）因严重肢体缺血而住院的晚期 PAD 患者（根据 Fontaine 量表至少为 IIb 期）。所有患者均进行了肺量测定以确认或排除 COPD。使用 ELISA 法测量 IL-6、IL-8 和 TNF-α 的血浆浓度。根据 COPD 状态和吸烟状态分别进行统计分析。
在所有 PAD 患者中，有 14 例（首次在 10 例中）被诊断为 COPD。所有患者均为吸烟者（46.7% 当前吸烟者，53.3% 戒烟者）。我们发现 FEV1%N（第一秒呼气量占正常百分比）与吸烟年限之间存在显著相关性（r = -0.39；p <0.05）。我们发现 COPD(+) 组与 COPD(-) 组的 IL-6（2.54 pg/ml 对 2.31 pg/ml）、IL-8（8.55 pg/ml 对 8.14 pg/ml）和 TNF-α（0.72 pg/ml 对 1.75 pg/ml）浓度相似（差异无统计学意义）。我们观察到测量标志物浓度之间存在显著正相关（p <0.05），并且无疼痛行走距离与这些标志物之间存在显著负相关。
我们的研究证实了 PAD 与 COPD 的共存。这些与吸烟有关的疾病的炎症特征相似。
