Alelú-Paz Raúl, Ashour Nadia, González-Corpas Ana, Ropero Santiago
Department of Biochemistry and Molecular Biology, School of Medicine, University of Alcalá, Carretera Madrid-Barcelona Km. 33.6, 28871 Madrid, Spain.
J Signal Transduct. 2012;2012:956958. doi: 10.1155/2012/956958. Epub 2012 Jul 17.
Gliomas are the most common type of primary brain tumor. Although tremendous progress has been achieved in the recent years in the diagnosis and treatment, its molecular etiology remains unknown. In this regard, epigenetics represents a new approach to study the mechanisms that control gene expression and function without changing the sequence of the genome. In the present paper we describe the main findings about the alterations of cell signaling pathways in the most aggressive glioma in the adult population, namely, glioblastoma, in which epigenetic mechanisms and the emerging role of cancer stem cell play a crucial function in the development of new biomarkers for its detection and prognosis and the corresponding development of new pharmacological strategies.
神经胶质瘤是最常见的原发性脑肿瘤类型。尽管近年来在诊断和治疗方面取得了巨大进展，但其分子病因仍然不明。在这方面，表观遗传学代表了一种新的研究方法，用于研究在不改变基因组序列的情况下控制基因表达和功能的机制。在本文中，我们描述了关于成人群体中最具侵袭性的神经胶质瘤，即胶质母细胞瘤细胞信号通路改变的主要研究结果，其中表观遗传机制和癌症干细胞的新作用在其检测和预后新生物标志物的开发以及相应新药理学策略的开发中发挥着关键作用。
