莫罗橙汁可预防小鼠脂肪肝。
Moro orange juice prevents fatty liver in mice.
机构信息
Department of Internal Medicine, University of Catania, Via Santa Sofia 78, Catania, Italy.
出版信息
World J Gastroenterol. 2012 Aug 7;18(29):3862-8. doi: 10.3748/wjg.v18.i29.3862.
Abstract
AIM
To establish if the juice of Moro, an anthocyanin-rich orange, may improve liver damage in mice with diet-induced obesity.
METHODS
Eight-week-old mice were fed a high-fat diet (HFD) and were administrated water or Moro juice for 12 wk. Liver morphology, gene expression of lipid transcription factors, and metabolic enzymes were assessed.
RESULTS
Mice fed HFD displayed increased body weight, insulin resistance and dyslipidemia. Moro juice administration limited body weight gain, enhanced insulin sensitivity, and decreased serum triglycerides and total cholesterol. Mice fed HFD showed liver steatosis associated with ballooning. Dietary Moro juice markedly improved liver steatosis by inducing the expression of peroxisome proliferator-activated receptor-α and its target gene acylCoA-oxidase, a key enzyme of lipid oxidation. Consistently, Moro juice consumption suppressed the expression of liver X receptor-α and its target gene fatty acid synthase, and restored liver glycerol-3-phosphate acyltransferase 1 activity.
CONCLUSION
Moro juice counteracts liver steatogenesis in mice with diet-induced obesity and thus may represent a promising dietary option for the prevention of fatty liver.
摘要
目的
研究富含花色苷的橙子莫罗汁是否可以改善饮食诱导肥胖小鼠的肝损伤。
方法
将 8 周龄的小鼠喂食高脂肪饮食（HFD），并连续 12 周给予水或莫罗汁。评估肝形态、脂质转录因子和代谢酶的基因表达。
结果
喂食 HFD 的小鼠体重增加、胰岛素抵抗和血脂异常。莫罗汁的摄入限制了体重的增加，增强了胰岛素的敏感性，并降低了血清甘油三酯和总胆固醇。喂食 HFD 的小鼠出现与气球样变相关的肝脂肪变性。饮食中的莫罗汁通过诱导过氧化物酶体增殖物激活受体-α及其靶基因酰基辅酶 A 氧化酶的表达，显著改善了肝脂肪变性，后者是脂质氧化的关键酶。一致地，莫罗汁的摄入抑制了肝 X 受体-α及其靶基因脂肪酸合酶的表达，并恢复了肝甘油-3-磷酸酰基转移酶 1 的活性。
结论
莫罗汁可抵抗饮食诱导肥胖小鼠的肝脂肪变性，因此可能是预防脂肪肝的一种有前途的饮食选择。
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