Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba, Japan.
Eye (Lond). 2012 Sep;26(9):1173-80. doi: 10.1038/eye.2012.170. Epub 2012 Aug 17.
BACKGROUND/AIM: The aim of this study is to report a reduction in the thickness of the ganglion cell complex (GCC) after vitrectomy with internal limiting membrane (ILM) peeling in eyes with idiopathic macular hole (MH).
Twenty-eight consecutive eyes with an idiopathic MH treated by vitrectomy with ILM peeling were studied. All eyes had an intravitreal injection of indocyanine green to make the ILM more visible. The best-corrected visual acuity (BCVA), GCC thickness measured by spectral domain optical coherence tomography, and retinal sensitivity measured by microperimetry were determined before and at 3 and 6 months after the vitrectomy.
The MH in all eyes was closed after the initial surgery. The BCVA was significantly improved at 3 and 6 months (P<0.001 and P<0.001, respectively). The thickness of the GCC was significantly reduced at 3 and 6 months postoperatively (P<0.001 and P<0.001, respectively). The GCC thickness was significantly correlated with the retinal sensitivity in the central 10 degrees at 6 months (r=0.55, P=0.004).
A reduction of the GCC thickness was observed after vitrectomy with ILM peeling for idiopathic MH.
背景/目的：本研究旨在报告特发性黄斑裂孔（MH）患者接受玻璃体切除联合内界膜（ILM）剥除术后，神经节细胞复合体（GCC）厚度的减少。
研究了 28 例连续接受玻璃体切除联合 ILM 剥除术治疗的特发性 MH 眼。所有眼均行吲哚菁绿眼内注射，使 ILM 更易见。在玻璃体切除术前和术后 3 个月和 6 个月，测量最佳矫正视力（BCVA）、谱域光相干断层扫描测量的 GCC 厚度和微视野计测量的视网膜敏感性。
所有眼的 MH 在初次手术后均闭合。BCVA 在术后 3 个月和 6 个月时显著提高（P<0.001 和 P<0.001）。术后 3 个月和 6 个月时 GCC 厚度显著降低（P<0.001 和 P<0.001）。术后 6 个月时，GCC 厚度与中央 10 度的视网膜敏感性显著相关（r=0.55，P=0.004）。
特发性 MH 患者接受玻璃体切除联合 ILM 剥除术后，GCC 厚度减少。
