Key laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai JiaoTong University, 800 Dongchuan Road, Shanghai, People's Republic of China.
BMC Vet Res. 2012 Sep 3;8:155. doi: 10.1186/1746-6148-8-155.
Noroviruses (NoVs) are members of the family Caliciviridae and are emerging enteric pathogens of humans and animals. Some porcine NoVs are genetically similar to human strains and are classified into GII, like most epidemic human NoVs. So far, PoNoV have been exclusively detected in fecal samples of adult pig without clinical signs.
Result showed that 2 of the 12 evaluated fecal samples were positive for PoNoVs, one of which was positive for PoNoV alone, and the other was coinfected with porcine circovirus and PoNoV. Phylogenetic and recombination analysis showed that the PoNoV positive alone strain was a recombinant new genotype strain. Experimental infection of miniature pigs with fecal suspensions confirmed that this strain can cause gastroenteritis in piglets.
This is the first report that recombinant new genotype PoNoV exised in pig herd of China, which cause diarrhea in pigs in nature condition. This find raised questions about the putative epidemiologic role of PoNoV.
诺如病毒（NoVs）是杯状病毒科的成员，是人类和动物新兴的肠道病原体。一些猪诺如病毒在基因上与人类株相似，被归类为 GII，与大多数流行的人类 NoVs 一样。到目前为止，PoNoV 仅在没有临床症状的成年猪的粪便样本中被检测到。
结果显示，在评估的 12 份粪便样本中，有 2 份检测出 PoNoVs 呈阳性，其中一份单独为 PoNoV 阳性，另一份与猪圆环病毒和 PoNoV 同时感染。系统进化和重组分析表明，单独阳性的 PoNoV 株是一种新的重组基因型株。用粪便悬浮液对小型猪进行的实验感染证实，该株可引起仔猪胃肠炎。
这是首次在中国猪群中发现存在重组新基因型的 PoNoV，该病毒可导致猪自然条件下腹泻。这一发现引发了人们对 PoNoV 潜在流行病学作用的质疑。
