Department of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
Carbohydr Polym. 2012 Oct 15;90(3):1362-70. doi: 10.1016/j.carbpol.2012.07.005. Epub 2012 Jul 11.
Silver-loaded dressings are designed to provide the same antimicrobial activity of topical silver, with the advantages of a sustained silver release and a reduced number of dressing changes. Moreover, such type of dressing must provide a moist environment, avoiding fiber shedding, dehydration and adherence to the wound site. Here we describe the preparation of a novel silver-loaded dressing based on a Gellan/Hyaff(®) (Ge-H) non woven, treated with a polyvinyl alcohol (PVA)/borax system capable to enhance the entrapment of silver in the dressing and to modulate its release. The new hydrophilic non woven dressings show enhanced water uptake capability and slow dehydration rates. A sustained silver release is also achieved. The antibacterial activity was confirmed on Staphylococcus aureus and Pseudomonas aeruginosa.
载银敷料旨在提供与局部应用银相同的抗菌活性，同时具有持续释放银和减少更换敷料次数的优点。此外，此类敷料必须提供湿润的环境，避免纤维脱落、脱水和黏附在伤口部位。在这里，我们描述了一种基于结冷胶/海姆（Gellan/Hyaff®）（Ge-H）无纺非织造布的新型载银敷料的制备方法，该非织造布用聚乙烯醇（PVA）/硼砂系统处理，能够增强银在敷料中的包埋并调节其释放。新型亲水无纺敷料具有增强的吸水性和缓慢的脱水率。还实现了持续的银释放。抗菌活性在金黄色葡萄球菌和铜绿假单胞菌上得到了证实。
