Aduba Donald C, Yang Hu
Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA.
Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA.
Bioengineering (Basel). 2017 Jan 18;4(1):1. doi: 10.3390/bioengineering4010001.
Wound dressings are critical for wound care because they provide a physical barrier between the injury site and outside environment, preventing further damage or infection. Wound dressings also manage and even encourage the wound healing process for proper recovery. Polysaccharide biopolymers are slowly becoming popular as modern wound dressings materials because they are naturally derived, highly abundant, inexpensive, absorbent, non-toxic and non-immunogenic. Polysaccharide biopolymers have also been processed into biomimetic platforms that offer a bioactive component in wound dressings that aid the healing process. This review primarily focuses on the fabrication and biocompatibility assessment of polysaccharide materials. Specifically, fabrication platforms such as electrospun fibers and hydrogels, their fabrication considerations and popular polysaccharides such as chitosan, alginate, and hyaluronic acid among emerging options such as arabinoxylan are discussed. A survey of biocompatibility and bioactive molecule release studies, leveraging polysaccharide's naturally derived properties, is highlighted in the text, while challenges and future directions for wound dressing development using emerging fabrication techniques such as 3D bioprinting are outlined in the conclusion. This paper aims to encourage further investigation and open up new, disruptive avenues for polysaccharides in wound dressing material development.
伤口敷料对于伤口护理至关重要，因为它们在伤口部位与外部环境之间提供了一道物理屏障，防止进一步损伤或感染。伤口敷料还能管理甚至促进伤口愈合过程，以实现妥善恢复。多糖生物聚合物作为现代伤口敷料材料正逐渐受到欢迎，因为它们天然衍生、来源丰富、价格低廉、具有吸水性、无毒且无免疫原性。多糖生物聚合物还被加工成仿生平台，在伤口敷料中提供有助于愈合过程的生物活性成分。本综述主要关注多糖材料的制备及其生物相容性评估。具体而言，讨论了诸如电纺纤维和水凝胶等制备平台、它们的制备要点，以及壳聚糖、海藻酸盐和透明质酸等常见多糖，还有诸如阿拉伯木聚糖等新兴选择。文中着重介绍了利用多糖天然衍生特性进行生物相容性和生物活性分子释放研究的概况，结论部分概述了使用3D生物打印等新兴制备技术开发伤口敷料所面临的挑战和未来方向。本文旨在鼓励进一步研究，并为多糖在伤口敷料材料开发中开辟新的、具有颠覆性的途径。
