Li Xu-Hong, Rong Peng-Fei, Jin He-Kun, Wang Wei, Tang Jin-Tian
Departments of Rehabilitation, and.
Exp Ther Med. 2012 Feb;3(2):279-284. doi: 10.3892/etm.2011.397. Epub 2011 Nov 30.
Magnetic fluid hyperthermia (MFH) induced by a magnetic field has become a new heating technology for the treatment of malignant tumors due to its ability to heat the tumor tissue precisely and properly, and due to its significant therapeutic effects. In this study, MFH induced by radiofrequency capacitive field (RCF) for the treatment of transplanted subcutaneous tumors in rats, was investigated. A total of 50 rats bearing subcutaneous tumors were randomly divided into five groups, including i) a pseudo-treatment (PT) control group, ii) magnetic fluid (MF) group, iii) pure hyperthermia (PH) group, iv) magnetic fluid hyperthermia 1 (MFH1) group, and v) magnetic fluid hyperthermia 2 (MFH2) group. Tumors were irradiated for 30 min in the MFH1 group 24 h following injection of MF. Tumors were irradiated for 30 min in the MFH2 group 24 h following injection of MF, and irradiation was repeated for 30 min 72 h following injection of MF. Tumor volumes, tumor volume inhibition ratios and survival times in the rat model were examined. Temperatures of tumor cores and rims both rapidly reached the desired temperature (∼50°C) for tumor treatment within 5 to 10 min in the MFH1 and MFH2 groups, and we maintained this temperature level by manually adjusting the output power (70-130 W). Tumor volumes of the MFH1 and MFH2 groups were reduced compared to those of the PT, MF and PH groups. The inhibitory effect on tumor growth in the MFH2 group (91.57%) was higher compared to that in the MFH1 group (85.21%) and the other groups. The survival time of the MFH2 group (51.62±2.28 days) and MFH1 group (43.10±1.57 days) was increased compared to that of the PH, MF and PT groups. The results obtained show that MFH induced by RCF may serve as a potential and promising method for the treatment of tumors.
磁场诱导的磁流体热疗（MFH）因其能够精确且适度地加热肿瘤组织以及显著的治疗效果，已成为一种治疗恶性肿瘤的新型加热技术。在本研究中，对射频电容场（RCF）诱导的MFH用于治疗大鼠移植性皮下肿瘤进行了研究。总共50只荷皮下肿瘤的大鼠被随机分为五组，包括：i）假治疗（PT）对照组，ii）磁流体（MF）组，iii）单纯热疗（PH）组，iv）磁流体热疗1（MFH1）组，以及v）磁流体热疗2（MFH2）组。在MFH1组中，注射MF后24小时对肿瘤进行30分钟照射。在MFH2组中，注射MF后24小时对肿瘤进行30分钟照射，并在注射MF后72小时重复照射30分钟。检测大鼠模型中的肿瘤体积、肿瘤体积抑制率和生存时间。在MFH1组和MFH2组中，肿瘤核心和边缘的温度在5至10分钟内迅速达到肿瘤治疗所需的温度（约50°C），并且我们通过手动调节输出功率（70 - 130 W）来维持该温度水平。与PT、MF和PH组相比，MFH1组和MFH2组的肿瘤体积减小。MFH2组对肿瘤生长的抑制作用（91.57%）高于MFH1组（85.21%）和其他组。与PH、MF和PT组相比，MFH2组（51.62±2.28天）和MFH1组（43.10±1.57天）的生存时间延长。所得结果表明，RCF诱导的MFH可能是一种有潜力且有前景的肿瘤治疗方法。
