School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
Plant Foods Hum Nutr. 2012 Dec;67(4):393-400. doi: 10.1007/s11130-012-0311-3.
This study was undertaken to determine the effects of chickpea albumin hydrolysate (CAH) on antihyperlipidemic and antitumor functions. The antihyperlipidemic results showed that CAH exhibited a dose dependent ability to decrease the levels of serum total cholesterol, triglyceride, LDL cholesterol (LDL-C), while increasing HDL cholesterol (HDL-C). Additionally, the appearance of the hyperlipidemic livers was ameliorated significantly. The antitumor results showed that CAH administration significantly increased the tumor inhibition rate and decreased tumor volume. CAH was also able to increase the spleen index and promote spleen lymphocyte proliferation. In addition, CAH treatment led to a remarkable rise in the superoxide dismutase (SOD) activity, while dramatically decreasing malondialdehyde (MDA) in the liver. Most importantly, we found that the physical conditions, such as appetite, activity, and coat luster of the mice in the CAH test group were better than those in the tumor control (TC) and positive control (PC) groups. These results taken together indicate that CAH warrants being further investigated and developed as an adjunctive element for hepatic lipid control, as well as antitumor and hypolipidemic therapies.
本研究旨在探讨鹰嘴豆白蛋白水解物（CAH）对降血脂和抗肿瘤功能的影响。降血脂结果表明，CAH 具有剂量依赖性降低血清总胆固醇、甘油三酯、低密度脂蛋白胆固醇（LDL-C）水平，同时增加高密度脂蛋白胆固醇（HDL-C）水平的能力。此外，高脂血症肝脏的外观也得到了显著改善。抗肿瘤结果表明，CAH 给药可显著提高肿瘤抑制率并降低肿瘤体积。CAH 还能增加脾脏指数，促进脾淋巴细胞增殖。此外，CAH 治疗导致超氧化物歧化酶（SOD）活性显著升高，同时肝脏丙二醛（MDA）含量显著降低。最重要的是，我们发现 CAH 实验组的小鼠的身体状况，如食欲、活动和毛色，均优于肿瘤对照组（TC）和阳性对照组（PC）。这些结果表明，CAH 值得进一步研究和开发，作为肝脂控制、抗肿瘤和降血脂治疗的辅助元素。
