Xirou Tina, Theodossiadis Panagiotis G, Apostolopoulos Michael, Kabanarou Stamatina A, Feretis Elias, Ladas Ioannis D, Koutsandrea Chrysanthi
Vitreoretinal Unit, Red Cross Hospital, University of Athens, Greece.
Clin Ophthalmol. 2012;6:1107-12. doi: 10.2147/OPTH.S32077. Epub 2012 Jul 20.
To report on the outcomes of vitrectomy and sulfur hexafluoride (SF(6)) gas tamponade for idiopathic macular holes with 2 days of face-down positioning.
This was a prospective, nonrandomized, observational sequential case-series study on 23 consecutive patients receiving macular hole surgery using 20% SF(6) and advised to stay in a face-down position for 2 days postoperatively (SF(6) group). These patients were compared to 23 consecutive patients who had previously undergone macular hole surgery, had received 14% C(3)F(8), and were advised to maintain a face-down position for 2 days (C(3)F(8) group). Patients in both groups underwent vitrectomy, internal limiting membrane peeling, and fluid gas exchange using either SF(6) or C(3)F(8.) Preoperative and postoperative data included best corrected visual acuity recorded in LogMAR units, slit-lamp biomicroscopy, and optical coherence tomography.
At a 6-month follow-up, macular hole closure was noted in 23/23 eyes (100%) and in 22/23 eyes (96%) in the SF(6) and C(3)F(8) groups, respectively. The improvement in visual acuity (measured through Snellen acuity lines both preoperatively until 6 months postoperatively) was 4.08 ± 2.31 (95% confidence interval [CI]: 3.08-5.08) for the SF(6) group and 2.87 ± 2.30 (95% CI: 1.87-3.86) for the C(3)F(8) group; this difference was not statistically significant (P = 0.06).
Vitrectomy with internal limiting membrane peeling and a short-acting gas tamponade using SF(6) with posture limitation for 2 days may give a high success rate in macular hole surgery.
报告玻璃体切除术联合六氟化硫（SF₆）气体填塞治疗特发性黄斑裂孔并采用2天俯卧位的治疗效果。
这是一项前瞻性、非随机、观察性序贯病例系列研究，对23例连续接受黄斑裂孔手术的患者使用20% SF₆，并建议术后俯卧位2天（SF₆组）。将这些患者与23例先前接受过黄斑裂孔手术、使用14% C₃F₈并建议保持俯卧位2天的连续患者进行比较（C₃F₈组）。两组患者均接受玻璃体切除术、内界膜剥除术，并使用SF₆或C₃F₈进行液气交换。术前和术后数据包括以LogMAR单位记录的最佳矫正视力、裂隙灯显微镜检查和光学相干断层扫描。
在6个月的随访中，SF₆组和C₃F₈组分别有23/23眼（100%）和22/23眼（96%）的黄斑裂孔闭合。SF₆组视力改善（术前至术后6个月通过Snellen视力表测量）为4.08±2.31（95%置信区间[CI]：3.08 - 5.08），C₃F₈组为2.87±2.30（95% CI：1.87 - 3.86）；差异无统计学意义（P = 0.06）。
玻璃体切除术联合内界膜剥除术以及使用SF₆进行短期气体填塞并限制体位2天，在黄斑裂孔手术中可能具有较高的成功率。
