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Validity of procalcitonin and C-reactive protein measurement when differentiating between benign and malignant pleural effusion.降钙素原和C反应蛋白检测在鉴别良恶性胸腔积液中的有效性。
Clin Lab. 2011;57(5-6):373-8.
2
The use of non-routine pleural fluid analysis in the diagnosis of pleural effusion.非常规胸腔积液分析在胸腔积液诊断中的应用。
Respir Med. 2010 Aug;104(8):1092-100. doi: 10.1016/j.rmed.2010.03.008. Epub 2010 Apr 13.
3
Pleural fluid tests to identify complicated parapneumonic effusions.胸腔积液检查以明确复杂性类肺炎旁胸腔积液。
Curr Opin Pulm Med. 2010 Jul;16(4):357-61. doi: 10.1097/MCP.0b013e328338a108.
4
Biomarkers of infection for the differential diagnosis of pleural effusions.用于胸腔积液鉴别诊断的感染生物标志物。
Eur Respir J. 2009 Dec;34(6):1383-9. doi: 10.1183/09031936.00197208. Epub 2009 Jun 18.
5
Tumor necrosis factor-alpha promotes malignant pleural effusion.肿瘤坏死因子-α促进恶性胸腔积液。
Cancer Res. 2007 Oct 15;67(20):9825-34. doi: 10.1158/0008-5472.CAN-07-1064.
6
Differential cytokine levels and immunoreactivities against Mycobacterium tuberculosis antigens between tuberculous and malignant effusions.结核性与恶性胸腔积液中细胞因子水平差异及针对结核分枝杆菌抗原的免疫反应性
Respir Med. 2008 Feb;102(2):280-6. doi: 10.1016/j.rmed.2007.08.016. Epub 2007 Oct 22.
7
Acute phase markers for the differentiation of infectious and malignant pleural effusions.用于鉴别感染性和恶性胸腔积液的急性期标志物。
Respir Med. 2007 May;101(5):910-8. doi: 10.1016/j.rmed.2006.09.019. Epub 2007 Jan 31.
8
Use of acute phase proteins in pleural effusion discrimination.急性期蛋白在胸腔积液鉴别中的应用。
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9
A simple C-reactive protein measurement for the differentiation between tuberculous and malignant pleural effusion.一种用于鉴别结核性和恶性胸腔积液的简单C反应蛋白检测方法。
Respirology. 2004 Mar;9(1):66-9. doi: 10.1111/j.1440-1843.2003.00521.x.
10
Tumor necrosis factor-alpha in pleural fluid: a marker of complicated parapneumonic effusions.胸腔积液中的肿瘤坏死因子-α：复杂性类肺炎性胸腔积液的一个标志物
Chest. 2004 Jan;125(1):160-4. doi: 10.1378/chest.125.1.160.

肿瘤坏死因子α和高敏C反应蛋白在渗出性胸腔积液诊断中的应用

Tumor necrosis factor alpha and high sensitivity C-reactive protein in diagnosis of exudative pleural effusion.

作者信息

Rezaeetalab Fariba, Parizadeh Seyed Mohhamad Reza, Esmaeely Habibollah, Akbari Hadi, Akbari Farzaneh, Saberi Soheila

机构信息

Assistant Professor, Department of Pulmonary Diseases, Lung Diseases and Tuberculosis Research Center (LD/TRC), School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

出版信息

J Res Med Sci. 2011 Nov;16(11):1405-9.

PMID:22973340
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3430056/
Abstract

BACKGROUND

Differentiation between exudative and transudative pleural effusions is the initial step in assessment of pleural effusion. The aim of this study was to determine whether high sensitivity C-reactive protein (hsCRP) and tumor necrosis factor α (TNFα) are diagnostic utilities for exudative pleural effusion.

METHODS

This experimental study assessed 79 patients with pleural effusion who underwent diagnostic evaluations at Imam Reza hospital, Mashhad, Iran in 2009-2010. The complete biochemical analysis of pleural fluid, pleural fluid culture, and pathological examination of pleural fluid and tissue were performed. Moreover, hsCRP and TNFα concentrations were measured in pleural fluid samples. The data was analyzed by student's t-test and Mann-Whitney test.

RESULTS

According to Light's criteria, 50 patients (63.30%) had exudative effusions while 29 subjects (36.70%) had transudative effusion. The pleural fluid concentrations of hsCRP and TNFα were significantly higher in the exudative group than the transudative group (p < 0.05). At a cutoff value of 5 mg/L for hsCRP, the results showed 94% sensitivity and 96.6% specificity. Regarding TNFα, a cutoff value of 12.9 ng/dl represented 96% sensitivity and 93% specificity.

CONCLUSIONS

HsCRP and TNFα levels may be considered as beneficial diagnostic factors for detecting exudative effusion in patients with pleural effusion.

摘要

背景

区分渗出性胸腔积液和漏出性胸腔积液是评估胸腔积液的第一步。本研究的目的是确定高敏C反应蛋白（hsCRP）和肿瘤坏死因子α（TNFα）是否可用于诊断渗出性胸腔积液。

方法

本实验性研究评估了2009年至2010年在伊朗马什哈德伊玛目礼萨医院接受诊断评估的79例胸腔积液患者。对胸腔积液进行了全面的生化分析、胸腔积液培养以及胸腔积液和组织的病理检查。此外，还测量了胸腔积液样本中的hsCRP和TNFα浓度。数据采用学生t检验和曼-惠特尼检验进行分析。

结果

根据Light标准，50例患者（63.30%）为渗出性胸腔积液，29例患者（36.70%）为漏出性胸腔积液。渗出性胸腔积液组的胸腔积液hsCRP和TNFα浓度显著高于漏出性胸腔积液组（p < 0.05）。hsCRP的临界值为5 mg/L时，结果显示敏感性为94%，特异性为96.6%。对于TNFα，临界值为12.9 ng/dl时，敏感性为96%，特异性为93%。

结论

HsCRP和TNFα水平可被视为检测胸腔积液患者渗出性胸腔积液的有益诊断因素。