Mason B H, Holdaway I M, Stewart A W, Neave L M, Kay R G
Department of Surgery, Auckland Hospital, New Zealand.
Br J Cancer. 1990 Jan;61(1):137-41. doi: 10.1038/bjc.1990.28.
The month of initial detection of tumour was recorded in 2,245 patients with breast cancer and correlated with survival over a follow-up period of 1.5-10 years. Women who initially detected their breast cancer in spring/summer had a significantly longer survival than those detecting their tumour at other times of the year. Overall, this relationship was independent of nodal status, tumour size and hormone receptor status. However, when patients were divided into groups the survival advantage was significantly associated with receptor status and age. Women aged greater than or equal to 50 years with ER-positive and PR-positive tumours who discovered their initial tumour in spring/summer had significantly better survival than those detecting their tumours at other times of the year. Survival was also longer in women aged less than 50 years with receptor-negative tumours who initially found their tumours in spring/summer compared with the rest of the year. This study suggests that the season of first detection of a breast cancer relates significantly to the later behaviour of the tumour, and may reflect seasonal changes in hormone dependent growth.
在2245例乳腺癌患者中记录了肿瘤首次被检测出的月份，并将其与1.5至10年随访期内的生存率进行关联分析。在春季/夏季首次检测出乳腺癌的女性，其生存期显著长于在一年中其他时间检测出肿瘤的女性。总体而言，这种关系独立于淋巴结状态、肿瘤大小和激素受体状态。然而，当将患者分组时，生存优势与受体状态和年龄显著相关。年龄大于或等于50岁、肿瘤雌激素受体（ER）阳性且孕激素受体（PR）阳性、在春季/夏季首次检测出肿瘤的女性，其生存期显著优于在一年中其他时间检测出肿瘤的女性。与一年中的其他时间相比，年龄小于50岁、受体阴性、在春季/夏季首次检测出肿瘤的女性生存期也更长。这项研究表明，乳腺癌首次被检测出的季节与肿瘤后期行为显著相关，可能反映了激素依赖性生长的季节性变化。
