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本文引用的文献

1
Hsa-miR-34b/c rs4938723 T>C and hsa-miR-423 rs6505162 C>A polymorphisms are associated with the risk of esophageal cancer in a Chinese population.人微小RNA-34b/c rs4938723 T>C和人微小RNA-423 rs6505162 C>A多态性与中国人群食管癌风险相关。
PLoS One. 2013 Nov 18;8(11):e80570. doi: 10.1371/journal.pone.0080570. eCollection 2013.
2
Epigenetic, genetic and environmental interactions in esophageal squamous cell carcinoma from northeast India.印度东北部食管鳞癌的表观遗传、遗传和环境相互作用。
PLoS One. 2013 Apr 15;8(4):e60996. doi: 10.1371/journal.pone.0060996. Print 2013.
3
Modeling gene-environment interactions in oral cavity and esophageal cancers demonstrates a role for the p53 R72P polymorphism in modulating susceptibility.口腔癌和食管癌中基因-环境相互作用的模型表明，p53基因R72P多态性在调节易感性方面发挥作用。
Mol Carcinog. 2014 Aug;53(8):648-58. doi: 10.1002/mc.22019. Epub 2013 Mar 8.
4
Esophageal cancer incidence and mortality in China, 2009.中国 2009 年食管癌发病与死亡分析
J Thorac Dis. 2013 Feb;5(1):19-26. doi: 10.3978/j.issn.2072-1439.2013.01.04.
5
Report of incidence and mortality in China cancer registries, 2009.中国癌症登记地区 2009 年肿瘤登记发病与死亡报告
Chin J Cancer Res. 2013 Feb;25(1):10-21. doi: 10.3978/j.issn.1000-9604.2012.12.04.
6
Interaction between alcohol consumption and CYP 2C19 gene polymorphism in relation to oesophageal squamous cell carcinoma.酒精摄入与 CYP2C19 基因多态性的相互作用与食管鳞状细胞癌的关系。
PLoS One. 2012;7(9):e43412. doi: 10.1371/journal.pone.0043412. Epub 2012 Sep 11.
7
Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions.全基因组关联分析鉴定中国人食管鳞癌的多个易感位点和基因-环境相互作用。
Nat Genet. 2012 Oct;44(10):1090-7. doi: 10.1038/ng.2411. Epub 2012 Sep 9.
8
Haplotype analysis of CTLA4 gene and risk of esophageal squamous cell carcinoma in Anyang area of China.中国安阳地区CTLA4基因单倍型分析与食管鳞状细胞癌风险
Hepatogastroenterology. 2011 Mar-Apr;58(106):432-7.
9
Polymorphisms in the cytotoxic T-lymphocyte antigen 4 gene and cancer risk: a meta-analysis.细胞毒性 T 淋巴细胞相关抗原 4 基因多态性与癌症风险：荟萃分析。
Cancer. 2011 Sep 15;117(18):4312-24. doi: 10.1002/cncr.25979. Epub 2011 Mar 8.
10
Global cancer statistics.全球癌症统计数据。
CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90. doi: 10.3322/caac.20107. Epub 2011 Feb 4.

细胞毒性T淋巴细胞抗原4（CTLA-4）+49 G>A（rs231775）基因多态性与食管癌的关联：从病例对照研究到荟萃分析

Association between Cytotoxic T-lymphocyte antigen 4 (CTLA-4) +49 G>A (rs231775) polymorphism and esophageal cancer: from a case-control study to a meta-analysis.

作者信息

Liu Chao, Wang Yafeng, Jiang Heping, Tang Weifeng, Chen Shuchen, Kang Mingqiang, Dong Changqing, Gu Haiyong

机构信息

Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University Zhenjiang, Jiangsu Province, China.

Department of Cardiology, The People's Hospital of Xishuangbanna Dai Autonomous Prefecture Jinghong, Yunnan Province, China.

出版信息

Int J Clin Exp Med. 2015 Oct 15;8(10):17664-73. eCollection 2015.

PMID:26770356
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4694256/
Abstract

The aim of this study was to evaluate the association between CTLA-4 +49 G>A polymorphism and esophageal cancer (EC) susceptibility in a hospital based case-control study and a subsequent meta-analysis. We implemented genotyping analyses for CTLA-4 +49 G>A polymorphism with 629 esophageal squamous cell carcinoma cases and 686 controls in a Chinese Han population. Polymerase chain reaction ligase detection reaction (PCR-LDR) method was used to identify genotypes of CTLA-4 +49 G>A polymorphism. We first assessed the association between CTLA-4 +49 G>A polymorphism and EC risk in a hospital based case-control study, and then performed a comprehensive meta-analysis to derive a more precise estimation. Our results demonstrated that CTLA-4 +49 G>A polymorphism was not associated with EC risk. This case-control study and further meta-analysis, failed to identify the association between CTLA-4 +49 G>A polymorphism and EC risk. And additional, further well designed studies with large sample sizes and detailed gene-environment data are required.

摘要

本研究旨在通过一项基于医院的病例对照研究及后续的荟萃分析，评估细胞毒性T淋巴细胞相关抗原4（CTLA-4）基因+49位点G>A多态性与食管癌（EC）易感性之间的关联。我们对中国汉族人群中629例食管鳞状细胞癌患者和686例对照进行了CTLA-4基因+49位点G>A多态性的基因分型分析。采用聚合酶链反应连接酶检测反应（PCR-LDR）方法鉴定CTLA-4基因+49位点G>A多态性的基因型。我们首先在一项基于医院的病例对照研究中评估CTLA-4基因+49位点G>A多态性与食管癌风险之间的关联，然后进行全面的荟萃分析以得出更精确的估计。我们的结果表明，CTLA-4基因+49位点G>A多态性与食管癌风险无关。这项病例对照研究及进一步的荟萃分析未能确定CTLA-4基因+49位点G>A多态性与食管癌风险之间的关联。此外，还需要更多设计良好、样本量较大且有详细基因-环境数据的研究。