• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

先天免疫对肺炎衣原体感染的反应：TLRs、NLRs 和炎性小体的作用。

Innate immune responses to Chlamydia pneumoniae infection: role of TLRs, NLRs, and the inflammasome.

机构信息

Division of Pediatric Infectious Diseases and Immunology, Cedars-Sinai Medical Center and David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90048, USA.

出版信息

Microbes Infect. 2012 Nov;14(14):1301-7. doi: 10.1016/j.micinf.2012.08.004. Epub 2012 Sep 5.

DOI:10.1016/j.micinf.2012.08.004
PMID:22985781
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3511600/
Abstract

Chlamydiae are important human pathogens that are responsible for a wide rage of diseases with a significant impact on public health. In this review article we highlight how recent studies have increased our knowledge of Chlamydia pneumoniae pathogenesis and mechanisms of innate immunity directed host defense against C. pneumoniae infection.

摘要

衣原体是重要的人类病原体，可引起广泛的疾病，对公共卫生有重大影响。在这篇综述文章中，我们强调了最近的研究如何增加了我们对肺炎衣原体发病机制和固有免疫机制的认识，固有免疫机制可针对肺炎衣原体感染发挥宿主防御作用。

相似文献

1
Innate immune responses to Chlamydia pneumoniae infection: role of TLRs, NLRs, and the inflammasome.先天免疫对肺炎衣原体感染的反应：TLRs、NLRs 和炎性小体的作用。
Microbes Infect. 2012 Nov;14(14):1301-7. doi: 10.1016/j.micinf.2012.08.004. Epub 2012 Sep 5.
2
Role of toll-like receptors in immune responses to chlamydial infections.Toll样受体在衣原体感染免疫反应中的作用。
Curr Pharm Des. 2008;14(6):593-600. doi: 10.2174/138161208783885344.
3
TLRs/NLRs: Shaping the landscape of host immunity.TLRs/NLRs：塑造宿主免疫的格局。
Int Rev Immunol. 2018 Jan 2;37(1):3-19. doi: 10.1080/08830185.2017.1397656. Epub 2017 Dec 1.
4
Caspase-1 dependent IL-1β secretion is critical for host defense in a mouse model of Chlamydia pneumoniae lung infection.半胱天冬酶-1 依赖性白细胞介素-1β分泌对于肺炎衣原体肺部感染小鼠模型中的宿主防御至关重要。
PLoS One. 2011;6(6):e21477. doi: 10.1371/journal.pone.0021477. Epub 2011 Jun 23.
5
New concepts in Chlamydia induced inflammasome responses.沙眼衣原体诱导的炎症小体反应的新概念。
Microbes Infect. 2018 Aug-Sep;20(7-8):424-431. doi: 10.1016/j.micinf.2017.11.011. Epub 2017 Dec 14.
6
Cell mediated immunity to Chlamydia pneumoniae.针对肺炎衣原体的细胞介导免疫
Scand J Infect Dis Suppl. 1997;104:18-21.
7
Innate immunity and vaccines in chlamydial infection with special emphasis on Chlamydia pneumoniae.衣原体感染中的天然免疫与疫苗，特别关注肺炎衣原体
FEMS Immunol Med Microbiol. 2009 Mar;55(2):167-77. doi: 10.1111/j.1574-695X.2008.00519.x. Epub 2009 Jan 13.
8
NOD-Like Receptors in Infection, Immunity, and Diseases.感染、免疫和疾病中的NOD样受体
Yonsei Med J. 2016 Jan;57(1):5-14. doi: 10.3349/ymj.2016.57.1.5.
9
The complement system, toll-like receptors and inflammasomes in host defense: three musketeers' one target.补体系统、 toll 样受体和炎症小体在宿主防御中的作用：三剑客的一个目标。
Int Rev Immunol. 2019;38(4):131-156. doi: 10.1080/08830185.2019.1609962. Epub 2019 May 8.
10
Role of chlamydial heat shock protein 60 in the stimulation of innate immune cells by Chlamydia pneumoniae.衣原体热休克蛋白60在肺炎衣原体刺激天然免疫细胞中的作用
Eur J Immunol. 2002 Sep;32(9):2460-70. doi: 10.1002/1521-4141(200209)32:9<2460::AID-IMMU2460>3.0.CO;2-M.

引用本文的文献

1
Identification of Key Genes Involved in Response to or spp. Infections in Human Cell Lines and in Mouse Organs.鉴定人细胞系和鼠器官中抗或 spp. 感染反应相关的关键基因。
Int J Mol Sci. 2023 Aug 27;24(17):13290. doi: 10.3390/ijms241713290.
2
is Prevalent in Symptomatic Coronary Atherosclerotic Plaque Samples Obtained From Directional Coronary Atherectomy, but its Quantity is Not Associated With Plaque Instability: An Immunohistochemical and Molecular Study.在经定向冠状动脉斑块旋切术获取的有症状冠状动脉粥样硬化斑块样本中普遍存在，但其数量与斑块不稳定性无关：一项免疫组织化学和分子研究。
Clin Pathol. 2022 Sep 26;15:2632010X221125179. doi: 10.1177/2632010X221125179. eCollection 2022 Jan-Dec.
3
Fascinating Molecular and Immune Escape Mechanisms in the Treatment of STIs (Syphilis, Gonorrhea, Chlamydia, and Herpes Simplex).性传播感染（梅毒、淋病、衣原体和单纯疱疹）治疗中的迷人分子和免疫逃逸机制。
Int J Mol Sci. 2022 Mar 24;23(7):3550. doi: 10.3390/ijms23073550.
4
is present in the dental plaque of periodontitis patients and stimulates an inflammatory response in gingival epithelial cells.存在于牙周炎患者的牙菌斑中，并刺激牙龈上皮细胞产生炎症反应。
Microb Cell. 2019 Mar 11;6(4):197-208. doi: 10.15698/mic2019.04.674.
5
Infection and Inflammatory Diseases.感染与炎症性疾病
For Immunopathol Dis Therap. 2016;7(3-4):237-254. doi: 10.1615/ForumImmunDisTher.2017020161.
6
Bacteria-Host Interactions in Multiple Sclerosis.多发性硬化症中的细菌与宿主相互作用
Front Microbiol. 2018 Dec 4;9:2966. doi: 10.3389/fmicb.2018.02966. eCollection 2018.
7
T-Cell-Intrinsic Receptor Interacting Protein 2 Regulates Pathogenic T Helper 17 Cell Differentiation.T 细胞内受体相互作用蛋白 2 调节致病性辅助性 T 细胞 17 分化。
Immunity. 2018 Nov 20;49(5):873-885.e7. doi: 10.1016/j.immuni.2018.08.022. Epub 2018 Oct 23.
8
Chlamydia pneumoniae Hijacks a Host Autoregulatory IL-1β Loop to Drive Foam Cell Formation and Accelerate Atherosclerosis.肺炎衣原体劫持宿主自调控的 IL-1β 环促进泡沫细胞形成并加速动脉粥样硬化。
Cell Metab. 2018 Sep 4;28(3):432-448.e4. doi: 10.1016/j.cmet.2018.05.027. Epub 2018 Jun 21.
9
The emerging role of ASC in dendritic cell metabolism during Chlamydia infection.ASC 在衣原体感染期间树突状细胞代谢中的新兴作用。
PLoS One. 2017 Dec 7;12(12):e0188643. doi: 10.1371/journal.pone.0188643. eCollection 2017.
10
Deviant Behavior: Tick-Borne Pathogens and Inflammasome Signaling.异常行为：蜱传病原体与炎性小体信号传导
Vet Sci. 2016 Sep 28;3(4):27. doi: 10.3390/vetsci3040027.

本文引用的文献

1
TLR2, but not TLR4, is required for effective host defence against Chlamydia respiratory tract infection in early life.TLR2 而非 TLR4，对于婴幼儿期呼吸道沙眼衣原体感染的有效宿主防御是必需的。
PLoS One. 2012;7(6):e39460. doi: 10.1371/journal.pone.0039460. Epub 2012 Jun 19.
2
Chlamydia pneumoniae-specific IgE is prevalent in asthma and is associated with disease severity.肺炎衣原体特异性 IgE 在哮喘中较为常见，且与疾病严重程度相关。
PLoS One. 2012;7(4):e35945. doi: 10.1371/journal.pone.0035945. Epub 2012 Apr 24.
3
The prevalence and identity of Chlamydia-specific IgE in children with asthma and other chronic respiratory symptoms.哮喘和其他慢性呼吸道症状患儿中特异性 IgE 衣原体的流行情况和种类。
Respir Res. 2012 Apr 18;13(1):32. doi: 10.1186/1465-9921-13-32.
4
Sphingolipid metabolism cooperates with BAK and BAX to promote the mitochondrial pathway of apoptosis.鞘脂代谢与 BAK 和 BAX 合作促进细胞凋亡的线粒体途径。
Cell. 2012 Mar 2;148(5):988-1000. doi: 10.1016/j.cell.2012.01.038.
5
Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis.氧化的线粒体 DNA 在细胞凋亡过程中激活 NLRP3 炎性体。
Immunity. 2012 Mar 23;36(3):401-14. doi: 10.1016/j.immuni.2012.01.009. Epub 2012 Feb 16.
6
Rac1 regulates the NLRP3 inflammasome which mediates IL-1beta production in Chlamydophila pneumoniae infected human mononuclear cells.Rac1 调节 NLRP3 炎性小体，后者介导肺炎衣原体感染的人单核细胞中白介素-1β的产生。
PLoS One. 2012;7(1):e30379. doi: 10.1371/journal.pone.0030379. Epub 2012 Jan 20.
7
Mitochondrial Rac1 GTPase import and electron transfer from cytochrome c are required for pulmonary fibrosis.线粒体 Rac1 GTP 酶的导入以及来自细胞色素 c 的电子传递对于肺纤维化是必需的。
J Biol Chem. 2012 Jan 27;287(5):3301-12. doi: 10.1074/jbc.M111.308387. Epub 2011 Dec 8.
8
Pathogens and atherosclerosis: update on the potential contribution of multiple infectious organisms to the pathogenesis of atherosclerosis.病原体与动脉粥样硬化：多种感染病原体在动脉粥样硬化发病机制中的潜在作用的最新研究进展。
Thromb Haemost. 2011 Nov;106(5):858-67. doi: 10.1160/TH11-06-0392. Epub 2011 Oct 20.
9
Mitochondria and the autophagy-inflammation-cell death axis in organismal aging.线粒体与衰老过程中自噬-炎症-细胞死亡轴
Science. 2011 Aug 26;333(6046):1109-12. doi: 10.1126/science.1201940.
10
Caspase-1 dependent IL-1β secretion is critical for host defense in a mouse model of Chlamydia pneumoniae lung infection.半胱天冬酶-1 依赖性白细胞介素-1β分泌对于肺炎衣原体肺部感染小鼠模型中的宿主防御至关重要。
PLoS One. 2011;6(6):e21477. doi: 10.1371/journal.pone.0021477. Epub 2011 Jun 23.