Sliva Daniel
Cancer Research Laboratory, Methodist Research Institute; ; Department of Medicine, and ; Indiana University Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA.
Exp Ther Med. 2010 May;1(3):407-411. doi: 10.3892/etm_00000063. Epub 2010 May 1.
Alternative cancer treatment with nutritional/dietary supplements containing a wide variety of herbal products is on the rise in Western countries. Recent epidemiological studies have suggested that mushrooms may prevent against different types of cancers. Phellinus linteus is a well-known Oriental medicinal fungus with a variety of biological activities, including immunomodulatory or direct antitumor activities. The activity of P. linteus and its extracts is associated with the presence of polysaccharides, their peptide/protein complexes and other low molecular weight complexes. Polysaccharide fractions isolated from P. linteus were found to be related to the increased activity of immune cells such as the production of cytokines by macrophages and B-cells or the increased cytotoxic activity of natural killer cells. Moreover, P. linteus was found to modulate the expression or activity of various genes involved in cell proliferation, apoptosis, angiogenesis, invasive behavior and chemoprevention. Finally, P. linteus extracts demonstrated tumor regression in three independent case reports, suggesting that an extract from P. linteus or a dietary supplement based on the extract from P. linteus may have potential use for the alternative treatment of cancer.
在西方国家，使用含有多种草药产品的营养/膳食补充剂进行癌症替代治疗的情况正在增加。最近的流行病学研究表明，蘑菇可能预防不同类型的癌症。桑黄是一种著名的东方药用真菌，具有多种生物活性，包括免疫调节或直接抗肿瘤活性。桑黄及其提取物的活性与多糖、其肽/蛋白质复合物和其他低分子量复合物的存在有关。从桑黄中分离出的多糖部分被发现与免疫细胞活性增加有关，如巨噬细胞和B细胞产生细胞因子，或自然杀伤细胞的细胞毒性活性增加。此外，发现桑黄可调节参与细胞增殖、凋亡、血管生成、侵袭行为和化学预防的各种基因的表达或活性。最后，在三个独立的病例报告中，桑黄提取物显示出肿瘤消退，这表明桑黄提取物或基于桑黄提取物的膳食补充剂可能具有用于癌症替代治疗的潜在用途。
