Zaizen Y, Ford E G, Costin G, Atkinson J B
Division of Pediatric Surgery, Childrens Hospital, Los Angeles, CA 90027.
J Pediatr Surg. 1990 Jan;25(1):70-4. doi: 10.1016/s0022-3468(05)80166-6.
Patients with significant malnutrition secondary to underlying disease may require major surgical intervention on an urgent basis. Nutritional restoration using enteral or intravenous alimentation requires a delay of 10 to 14 days and is frequently not practical. With the availability of human growth hormone (GH) produced by recombinant DNA technology, this study was undertaken to evaluate the effect of exogenous GH on wound tensile strength in a rat model. Fifty-four animals were divided into three groups: group I, normal nourished control; group II, malnourished; group III, malnourished, rat GH treated (1 mg GH administered 3 days preoperative and 5 days postoperative celiotomy). Wound tensile strength was measured at 6 days postoperatively. Wound strengths in malnourished rats were significantly less than in normal controls (P less than .001). With the administration of growth hormone in group III, wound strength was significantly improved when slightly improved over normally nourished controls (P less than .05). A dose response curve demonstrated progressive improvement in wound tensile strength from 0.01 mg/d to 1.0 mg/d. Thus growth hormone administration to malnourished animals significantly enhances wound strength. With the availability of recombinant produced human GH these observations may be clinically applicable.
因基础疾病导致严重营养不良的患者可能需要紧急进行大型手术干预。使用肠内或静脉营养进行营养恢复需要延迟10至14天，且通常不切实际。随着通过重组DNA技术生产的人生长激素（GH）的出现，本研究旨在评估外源性GH对大鼠模型伤口抗张强度的影响。54只动物被分为三组：第一组，正常营养对照组；第二组，营养不良组；第三组，营养不良且接受大鼠GH治疗组（术前3天和术后5天腹腔切开术时给予1mg GH）。术后6天测量伤口抗张强度。营养不良大鼠的伤口强度明显低于正常对照组（P<0.001）。在第三组中给予生长激素后，伤口强度明显改善，略高于正常营养对照组（P<0.05）。剂量反应曲线表明，从0.01mg/d到1.0mg/d，伤口抗张强度逐渐提高。因此，给营养不良的动物注射生长激素可显著增强伤口强度。随着重组生产的人生长激素的出现，这些观察结果可能具有临床应用价值。
