Key Laboratory of Environmental Medicine Engineering in Ministry of Education, Department of Biochemistry and Molecular Biology, Medical School of Southeast University, Nanjing 210009, China.
Oxid Med Cell Longev. 2012;2012:564093. doi: 10.1155/2012/564093. Epub 2012 Sep 11.
All organisms respond to environmental stresses (e.g., heavy metal, heat, UV irradiation, hyperoxia, food limitation, etc.) with coordinated adjustments in order to deal with the consequences and/or injuries caused by the severe stress. The nematode Caenorhabditis elegans often exerts adaptive responses if preconditioned with low concentrations of agents or stressor. In C. elegans, three types of adaptive responses can be formed: hormesis, cross-adaptation, and dietary restriction. Several factors influence the formation of adaptive responses in nematodes, and some mechanisms can explain their response formation. In particular, antioxidation system, heat-shock proteins, metallothioneins, glutathione, signaling transduction, and metabolic signals may play important roles in regulating the formation of adaptive responses. In this paper, we summarize the published evidence demonstrating that several types of adaptive responses have converged in C. elegans and discussed some possible alternative theories explaining the adaptive response control.
所有生物体都会对环境压力（例如重金属、高温、紫外线辐射、高氧、食物限制等）做出协调的调整，以应对严重压力造成的后果和/或损伤。线虫秀丽隐杆线虫在受到低浓度药剂或应激源预处理时，通常会产生适应性反应。在线虫中，可以形成三种类型的适应性反应：毒物兴奋效应、交叉适应和饮食限制。有几个因素会影响线虫适应性反应的形成，有些机制可以解释其反应的形成。特别是抗氧化系统、热休克蛋白、金属硫蛋白、谷胱甘肽、信号转导和代谢信号可能在调节适应性反应的形成中发挥重要作用。本文总结了已发表的证据，证明了几种类型的适应性反应在秀丽隐杆线虫中已经趋同，并讨论了一些可能的替代理论来解释适应性反应的控制。
