Laboratorio de Gastroenterologia Clínica e Experimental - LIM 07, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
Clinics (Sao Paulo). 2012 Sep;67(9):1013-8. doi: 10.6061/clinics/2012(09)05.
Celiac disease is a permanent enteropathy caused by the ingestion of gluten, which leads to an immunemediated inflammation of the small intestine mucosa. The prevalence of celiac disease varies among different nations and ethnic backgrounds, and its diversity is determined by genetic and environmental factors. São Paulo city is one of the largest cities in the world, with a vast population and an important history of internal migratory flow from other Brazilian regions, as well as immigration from other, primarily European, countries, resulting in significant miscegenation. The aim of the present study was to estimate the prevalence of adults with undiagnosed celiac disease among blood donors of São Paulo by collecting information on the ancestry of the population studied.
The prevalence of celiac disease was assessed by screening for positive IgA transglutaminase and IgA endomysium antibodies in 4,000 donors (volunteers) in the Fundação Pró-Sangue Blood Center of São Paulo, São Paulo, Brazil. The antibody-positive subjects were asked to undergo a small bowel biopsy.
Of the 4,000 subjects, twenty-four had positive tests, although both antibody tests were not always concordant. For example, ten subjects were positive for IgA tissue transglutaminase only. In twenty-one positive patients, duodenal biopsies were performed, and the diagnosis of celiac disease was confirmed in fourteen patients (Marsh criteria modified by Oberhuber). In this group, 67% claimed to have European ancestry, mainly from Italy, Portugal and Spain.
The prevalence of celiac disease is at least 1:286 among supposedly healthy blood bank volunteers in São Paulo, Brazil.
乳糜泻是一种由麸质摄入引起的永久性肠病，导致小肠黏膜的免疫介导炎症。乳糜泻的患病率在不同国家和种族背景之间存在差异，其多样性由遗传和环境因素决定。圣保罗市是世界上最大的城市之一，拥有庞大的人口和来自巴西其他地区以及其他国家（主要是欧洲国家）的重要内部移民流动历史，导致了显著的混合。本研究旨在通过收集研究人群的祖先信息，估计圣保罗献血者中未确诊的乳糜泻成年患者的患病率。
在巴西圣保罗市 Fundação Pró-Sangue 献血中心，对 4000 名（志愿者）献血者进行 IgA 转谷氨酰胺酶和 IgA 内肌层抗体的阳性筛查，以评估乳糜泻的患病率。对抗体阳性的受试者进行小肠活检。
在 4000 名受试者中，有 24 名检测结果为阳性，尽管两种抗体检测并不总是一致。例如，有 10 名受试者仅 IgA 组织转谷氨酰胺酶阳性。在 21 名阳性患者中，进行了十二指肠活检，14 名患者（经 Oberhuber 修改的 Marsh 标准）确诊为乳糜泻。在这一组中，67%的人声称有欧洲血统，主要来自意大利、葡萄牙和西班牙。
在巴西圣保罗市的所谓健康献血者志愿者中，乳糜泻的患病率至少为 1:286。
